Sökning: "Complex transcription"

Visar resultat 21 - 25 av 515 avhandlingar innehållade orden Complex transcription.

  1. 21. Rule-based Models of Transcriptional Regulation and Complex Diseases : Applications and Development

    Författare :Susanne Bornelöv; Jan Komorowski; Claes Wadelius; Joanna Polanska; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone modification; Transcription factor; Transcriptional regulation; Next-generation sequencing; Feature selection; Machine learning; Rule-based classification; Asthma; Allergy; Bioinformatik; Bioinformatics;

    Sammanfattning : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. LÄS MER

  3. 22. Mediator and its role in non-coding RNA and chromatin regualtion

    Författare :Jonas O P Carlsten; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mediator; transcription; centromere; telomere; tRNA; exosome;

    Sammanfattning : Mediator is a multiprotein complex required for the regulation of RNA Polymerase II (Pol II) transcription. Mediator transmits regulatory signals from activators and repressors to the Pol II machinery at the promoter, but the complex has also many other functions related to control of gene transcription. LÄS MER

  4. 23. Functions of Transcriptional Co-regulators in Drosophila development

    Författare :Tobias Lilja; Mattias Mannervik; Ze'ev Paroush; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transcription; Co-regulator; Development; Drosophila; Developmental biology; Utvecklingsbiologi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Sammanfattning : During Drosophila development, regulation of gene expression through interplay between transcriptional activators and repressors is generating complex patterns of gene expression that leads to cell differentiation. For proper control of transcription, transcription factors bind to DNA at control regions, so called Cis Regulatory Modules (CRM). LÄS MER

  5. 24. The Multifunctional Nature of the Adenovirus L4-22K Protein

    Författare :Susan Lan; Göran Akusjärvi; Per Elias; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-22K; MLP; RNA; transcription; splicing; adenovirus;

    Sammanfattning : The adenovirus major late transcription unit (MLTU) encodes for most of the mRNAs that are translated into the structural proteins of the virus capsid. Transcription from the MLTU is directed by the major late promoter (MLP), which is highly activated during the late phase of infection. LÄS MER

  7. 25. Chromatin Remodeling by BRG1 and SNF2H : Biochemistry and Function

    Författare :Patrik Asp; Ann-Kristin Östlund Farrants; Anthony Imbalzano; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chromatin; chromatin remodeling; SWI SNF; ISWI; BRG1; SNF2H; Prp8; RNA; transcription; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Chromatin is a highly dynamic, regulatory component in the process of transcription, repair, recombination and replication. The BRG1 and SNF2H proteins are ATP-dependent chromatin remodeling proteins that modulate chromatin structure to regulate DNA accessibility for DNA-binding proteins involved in these processes. LÄS MER