Sökning: "Complex transcription"

Visar resultat 6 - 10 av 515 avhandlingar innehållade orden Complex transcription.

  1. 6. Regulation of RNA polymerase I and RNA polymerase III transcription by the chromatin remodelling complex B-WICH

    Författare :Fatemeh Sadeghifar; Ann-Kristin Östlund Farrants; Magdalena Boguta; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; B-WICH; Chromatin remodelling; ribosomal genes; transcription; Cell Biology; cellbiologi;

    Sammanfattning : Ribosomal biogenesis is an important process which determines the rate of cell growth and is involved in cell response to proliferation, differentiation, cellular nutritional state and stress. The chromatin remodelling complex B-WICH composed of WSTF, SNF2h and NM1 is involved in transcription by the RNA pol I and RNA pol III. LÄS MER

  3. 7. Viral Strategies to Regulate Transcription and Pre-mRNA Splicing

    Författare :Shaoan Fan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Adenovirus E1B-55kDa; E4-ORF4; E4-ORF6 proteins; L1 mRNA; Polyoma virus small T antigen; regulation; transcription; splicing; PP2A; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : A typical DNA virus encodes for a few key regulatory proteins that modify the host cell biosynthetic machinery to achieve a selective viral gene statement. One such example is illustrated by the adenovirus E4-ORF4 protein, which form an enzymatically active complex with the serine and threonine-specific protein phosphatase 2A (PP2A). LÄS MER

  4. 8. Elucidation of complex diseases by machine learning

    Författare :Karolina Smolinska Garbulowska; Jan Komorowski; Claes Wadelius; Tuuli Lappalainen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; machine learning; complex disease; multi-omics; regulatory element; gene regulation; transcription factor motif; networks; rough sets; Bioinformatics; Bioinformatik;

    Sammanfattning : Uncovering the interpretability of models for complex health-related problems is a crucial task that is often neglected in machine learning (ML). The amount of available data makes the problem even more complicated. LÄS MER

  5. 9. Chromatin remodelling of ribosomal genes - be bewitched by B-WICH

    Författare :Anna Vintermist; Ann-Kristin Östlund Farrants; Ross D. Hannan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chromatin remodelling; ribosomal genes; rDNA; transcription; RNA polymerase I transcription; RNA polymerase III transcription; Cell Biology; cellbiologi;

    Sammanfattning : Transcription of the ribosomal genes accounts for the majority of transcription in the cell due to the constant high demand for ribosomes. The number of proteins synthesized correlates with an effective ribosomal biogenesis, which is regulated by cell growth and proliferation. LÄS MER

  7. 10. The interplay of transcription and chromatin regulation during embryonic development

    Författare :George Hunt; Mattias Mannervik; Eileen Furlong; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transcription; chromatin; chromatin-modifiers; p300 CBP; Polycomb repression; promoter proximal Pol II pausing; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : A fascinating aspect of multicellular development is the production of diverse cell types from an identical DNA genome, which depends on the ability to express different complements of genes across space and time. This thesis tries to address how the genome, within the chromatin structure that envelops it, is regulated to direct this complex process. LÄS MER