Sökning: "Caspase-8"

Visar resultat 1 - 5 av 24 avhandlingar innehållade ordet Caspase-8.

  1. 1. Tissue Factor Biological Functions Coagulation Activity in Microparticles and Signaling with Focus On Migration and Apoptosis

    Detta är en avhandling från Uppsala : Universitetsbiblioteket

    Författare :Mikael Åberg; Uppsala universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue factor; Apoptosis; Migration; Chemotaxis; Simvastatin; Platelet Derived Growth Factor; Cell Signaling; Microparticles; Prostasomes; Trombosis; Coagulation; Prostate Cancer; Breast Cancer; Caspase-3; Caspase-8; NFkappaB; PAR2; Transactivation; Monocytes; MEDICINE Chemistry Clinical chemistry; MEDICIN Kemi Klinisk kemi;

    Sammanfattning : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. TF is over-expressed on many malignant cells and apart from increasing the risk of thrombosis, the presence of TF/FVIIa also promotes the progression of cancer and metastasis by intracellular signaling. LÄS MER

  2. 2. Studies on caspase signaling in microglia

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Författare :Johanna Rodhe; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The aim of this thesis is to investigate the roles of caspase-8 and caspase-3 in microglia and in brain disorders, beyond their function in apoptosis. Microglia are resident immune cells of the central nervous system and act as the first line of defense against invading pathogens and other types of brain insults. LÄS MER

  3. 3. Regulation of neutrophil apoptosis

    Detta är en avhandling från Maria Alvarado-Kristensson, experimentall pathology, Lund University, U-MAS, entrance 78, 205 02 Malmö

    Författare :Maria Alvarado-Kristensson; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; PP2A; p38 MAPK; caspases; signal transduction; inflammation; Apoptosis; human neutrophils;

    Sammanfattning : The human neutrophil is the most abundant granulocyte and the major type of cell involved in an acute inflammatory response. Neutrophils are armed with various systems of enzymes, that can find and kill pathogens, but unfortunately, these "weapons" cannot distinguish between the host tissues and the "invaders. LÄS MER

  4. 4. Lysosomal Membrane Stability and Cathepsins in Cell Death

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Hanna Appelqvist; Linköpings universitet.; Linköpings universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Lysosomes are acidic organelles that are critically involved in a number of physiological processes, including macromolecule degradation, endocytosis, autophagy, exocytosis and cholesterol homeostasis. Several pathological conditions, such as cancer, neurodegenerative disorders and lysosomal storage diseases, involve lysosomal disturbances, indicating the importance of the organelle for correct cellular function. LÄS MER

  5. 5. DNA damage-induced cell death : The role of caspase-2

    Detta är en avhandling från Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Författare :Helin Vakifahmetoglu; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; caspase-2; DNA damage; mitotic catastrophe; p53;

    Sammanfattning : Activation of a family of cysteine proteases, called caspases, is an important event during apoptosis. In comparison to other caspases, less is known about regulatory functions of caspase-2. Previous studies from our group established caspase-2 as an essential apical regulator of apoptosis triggered by DNA damage. LÄS MER