Sökning: "Chemotaxis"

Visar resultat 1 - 5 av 95 avhandlingar innehållade ordet Chemotaxis.

1. 1. Neutrophil chemotaxis. Analyses of neutrophil chemotaxis i a new fluid gradient chamber

   Författare :Reza Ebrahimzadeh Pirshahid; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell movement; Chemotaxis; Leukocyte; Neutrophil; Human; Filter; Methods; N-Formylmethionine-Leucyl-Phenylalanine; Normal distribution; Partial differential equation;

   Sammanfattning : The leukocytes have, as part of their function in immune system, the ability to leave the bloodstream, penetrate the vascular wall and migrate towards extravascular targets. This behaviour of the leukocytes has been extensively studied both in vivo and in vitro since the 19th century but the mechanisms underlying leukocyte migration are not yet fully understood. LÄS MER

3. 2. Neutrophil Chemotaxis and Respiratory Burst in Term and Preterm Newborn Infants

   Författare :Maria Stålhammar; Richard Sindelar; Jens Schollin; Uppsala universitet; []
   Nyckelord :innate immunity; neutrophil; term newborn infants; preterm newborn infants; chemotaxis; respiratory burst; reactive oxygen species; cell surface receptor; IL-8; bacterial N-formyl peptide;

   Sammanfattning : Neutrophil activation is the most important initial immune defense against invading microbes in newborn infants. The reduced neutrophil migration and uncontrolled regulation of reactive oxygen species (ROS) production observed in neonates, could result in a diminished infectious response or in tissue damage. LÄS MER

4. 3. Tissue Factor Biological Functions : Coagulation Activity in Microparticles and Signaling with Focus On Migration and Apoptosis

   Författare :Mikael Åberg; Agneta Siegbahn; Carl-Henrik Heldin; Teet Velling; Björn Dahlbäck; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue factor; Apoptosis; Migration; Chemotaxis; Simvastatin; Platelet Derived Growth Factor; Cell Signaling; Microparticles; Prostasomes; Trombosis; Coagulation; Prostate Cancer; Breast Cancer; Caspase-3; Caspase-8; NFkappaB; PAR2; Transactivation; Monocytes; Clinical chemistry; Klinisk kemi;

   Sammanfattning : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. TF is over-expressed on many malignant cells and apart from increasing the risk of thrombosis, the presence of TF/FVIIa also promotes the progression of cancer and metastasis by intracellular signaling. LÄS MER

5. 4. C5a Receptor Expression in Severe Sepsis and Septic Shock

   Författare :Mia Furebring; Jan Sjölin; Per Folllin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; C5a receptor; granulocyte; severe sepsis; septic shock; chemotaxis; anti-C5a treatment; ex vivo incubation; C5a; interleukin-8; LPS; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar;

   Sammanfattning : In patients with sepsis, the activation of the cascade systems, for example the complement system with the generation of C5a, is followed by a state of immunosuppression with impaired bactericidal capacity caused by suppression of the neutrophil granulocytes. To inhibit the C5a-induced systemic inflammatory and the following anti-inflammatory responses, different anti-C5a strategies have been successful in experimental models of sepsis. LÄS MER

7. 5. Myofibroblasts and the Vascular Endothelium : Impact of Fibrin Degradation Products and miRNA on Vascular Motility and Function

   Författare :Peder Fredlund Fuchs; Pär Gerwins; Johan Kreuger; Arne Östman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Angiogenesis; Vascular biology; Chemotaxis; Endothelial cell; Myofibroblast; Wound healing; miRNA; Heparan sulfate; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Angiogenesis is the formation of new blood vessels from pre-existing vasculature and is important during development as well as wound healing and tissue remodeling. Angiogenesis also occurs during pathological conditions such as diabetic retinopathy and cancer. LÄS MER