Sökning: "Caspase-8"

Visar resultat 11 - 15 av 24 avhandlingar innehållade ordet Caspase-8.

  1. 11. Neuroblastoma as a target for effector mechanisms of the immune system

    Författare :Anna De Geer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma (NB) is the most common solid extracranial tumor in children. Despite intensive multimodal treatment, the prognosis for high-risk NB patients remains poor and therefore new treatment modalities are needed. The main aim of my studies was to assess NB as a target for cytotoxic T lymphocyte (CTL)-mediated immunotherapy. LÄS MER

  3. 12. To catch a killer : on the mechanisms of interferon alpha induced apoptosis

    Författare :Lena Thyrell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A major clinical problem regarding treatment of malignant tumours is primary or secondary resistance to therapy. Anti-tumour drugs act primarily by induction of apoptosis. However, the knowledge of how various substances induce apoptosis is still incomplete, and so is the reason for the great variation in cellular sensitivity to these drugs. LÄS MER

  4. 13. On neuroinflammation in psychotic disorders

    Författare :Carl Sellgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroinflammation has been implicated in several psychiatric conditions. Based on experimental studies, the glia-derived tryptophan metabolite kynurenic acid (KYNA) may be especially relevant for positive psychotic symptoms and impaired executive functioning. LÄS MER

  5. 14. Apoptotic signaling in lung carcinoma cells : with focus on mechanisms of radioresistance

    Författare :Jessica Ekedahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis, IR-induced apoptotic signaling was studied in a panel of lung carcinoma cell lines. The goal was not only to achieve a better understanding of the process, but also to identify possible targets for pharmacological modulation to enhance the efficiency of radiotherapy. LÄS MER

  7. 15. Interactions between neuroblastoma and the immune system : cellular pathways and mediators

    Författare :Lena-Maria Carlson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma (NB) is an embryonal tumor of early childhood arising in tissues of the sympathetic nervous system, such as the adrenal gland and paraspinal ganglia. It is the most common extra-cranial solid tumor of childhood, and 10-20 children are diagnosed with NB each year in Sweden. LÄS MER