Sökning: "CRPC"

Visar resultat 11 - 15 av 16 avhandlingar innehållade ordet CRPC.

  1. 11. How to model temporal changes in epidemiological data : Treatment trajectories in men with prostate cancer

    Författare :Eugenio Ventimiglia; Pär Stattin; Paul C. Lambert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; state transition model; life expectancy; active surveillance; watchful waiting;

    Sammanfattning : Owing to the improvements in detection, diagnostics, and treatment, many men currently diagnosed with prostate cancer (PCa) have a low risk of PCa death. For many men PCa has become a chronic disease with a small risk of progression that remains even decades after date of diag-nosis. LÄS MER

  3. 12. Cellular mechanisms of taxane therapy in castration resistant prostate cancer

    Författare :Martina Tinzl; Malmö (Abrahamsson) Urologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; chemotherapy; taxane; c-jun; androgen receptor; PSA;

    Sammanfattning : Chemotherapy of castration resistant prostate cancer (CRPC) is based on taxane formulations worldwide. Only 30-50 % of patients respond to this therapy and the exact cellular mechanisms of taxane resistance in PC cells are not fully elucidated. There is convincing evidence that androgen receptor (AR) is affected by exposure to these compounds. LÄS MER

  4. 13. Prostate cancer incidence, treatment and mortality : Empirical longitudinal register-based studies and methods for handling missing data

    Författare :Marcus Westerberg; Rolf Larsson; Hans Garmo; Pär Stattin; Jimmy Olsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; statistics; mathematics; prostate cancer; missing data; survival analysis; longitudinal models; incidence; treatment; mortality; Mathematical Statistics; Matematisk statistik; Statistics; Statistik; Urologi; Urology; Epidemiologi; Epidemiology;

    Sammanfattning : The diagnostic activity for prostate cancer has increased substantially in Sweden, primarily due to increased use of prostate-specific antigen (PSA) testing in asymptomatic men, and this has led to a large increase in diagnoses. There have also been changes in the diagnostic workup, guidelines, treatment strategies, and more effective treatments have been introduced in different phases of the disease. LÄS MER

  5. 14. MicroRNA expression profiles in prostate cancer bone metastases : functional effects of microRNA-23c, -375, and -4328

    Författare :Helena Järemo; Pernilla Wikström; Maria Brattsand; Anders Bergh; Elin Thysell; Guido Jenster; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer bone metastases; microRNA; metastatic subtypes; extracellular vesicles; Pathology; patologi;

    Sammanfattning : Non-coding microRNAs (miRNAs) function as post-transcriptional regulators of gene expression by interacting with messenger RNA. Dysregulation of miRNAs has many possible consequences, including tumor-suppressive or -promoting ones, and restoring or preventing the effects of miRNA alteration has therapeutic potential. LÄS MER

  7. 15. Studies on the molecular and functional properties of exosomes in the metastatic prostate cancer bone microenvironment

    Författare :Ioulia Vardaki; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostate cancer is the most common cancer type and the second leading cancer related cause of death worldwide in men. Prostate cancer patients initially respond to standard treatment (e.g., hormonal, surgery/irradiation) but about 30% of them will develop resistance and progress to metastatic Castration Resistant Prostate Cancer (mCRPC). LÄS MER