Sökning: "taxane"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet taxane.

  1. 1. Taxane-induced pain : Experiences of women with breast cancer and nurses providing their care

    Författare :Susanne Hellerstedt Börjesson; Karin Nordin; Cecilia Arving; Marie-Louise Fjällskog; Magnus Peterson; Joakim Öhlen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; taxane-induced pain; lifeworld research; pain assessment; caring; Caring Sciences; Vårdvetenskap;

    Sammanfattning : Breast cancer patients receiving taxane chemotherapy run a substantial risk of develop taxane-induced pain, but little is known about women’s experiences of such pain. The aim of this thesis was to explore women’s acute and longstanding experiences of taxane-induced pain, to evaluate the pain intensity and distribution using different assessment methods, and to study nurses´ perceptions of taxane-induced pain in people with breast cancer. LÄS MER

  3. 2. Cellular mechanisms of taxane therapy in castration resistant prostate cancer

    Författare :Martina Tinzl; Malmö (Abrahamsson) Urologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; chemotherapy; taxane; c-jun; androgen receptor; PSA;

    Sammanfattning : Chemotherapy of castration resistant prostate cancer (CRPC) is based on taxane formulations worldwide. Only 30-50 % of patients respond to this therapy and the exact cellular mechanisms of taxane resistance in PC cells are not fully elucidated. There is convincing evidence that androgen receptor (AR) is affected by exposure to these compounds. LÄS MER

  4. 3. Taxane-Induced Peripheral Neuropathy among Early-Stage Breast Cancer Survivors : Prevalence, Risk Factors, Quality of Life and Genetic Prediction Models

    Författare :Kristina Engvall; Elisabeth Åvall-Lundqvist; Henrik Gréen; Niklas Loman; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early-stage breast cancer; Taxane; Chemotherapy-induced peripheral neuropathy; Risk factors; Polygenic prediction models;

    Sammanfattning : Background: Taxane-induced peripheral neuropathy (TIPN) is a common and distressful side effect. Little is known on how long TIPN persist and its effect on health-related quality of life (HRQL). LÄS MER

  5. 4. Pharmacometric Models for Antibody Drug Conjugates and Taxanes in HER2+ and HER2- Breast Cancer

    Författare :Brendan Bender; Lena Friberg; Mats Karlsson; Jin Jin; Oscar della Pasqua; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometric; PKPD; model; breast cancer; T-DM1; thrombocytopenia; hepatotoxiticy; HER2; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : In oncology, there is a need to optimize drug treatment for efficient eradication of tumors, minimization of adverse effects (AEs), and prolonging patient survival. Pharmacometric models can be developed to streamline information between drug development phases, describe and quantify response to treatment, and determine dose regimens that balance toxicity and efficacy. LÄS MER

  7. 5. Molecular signatures of progression and chemoresistance in epithelial ovarian carcinoma

    Författare :My Björklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epithelial ovarian carcinoma (EOC) is a heterogeneous disease generally classified into five histopathological subtypes; low- and high-grade serous, endometrioid, clear cell and mucinous carcinomas. Although each subtype has distinct clinical and molecular characteristics, they are all treated with surgery and platinum/ taxane chemotherapy. LÄS MER