Sökning: "PIP3"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet PIP3.

  1. 1. Oscillatory Signaling and Insulin Secretion from Single ß-cells

    Författare :Olof Idevall Hagren; Anders Tengholm; Erik Gylfe; Leslie Satin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; Ca2 ; oscillations; beta-cell; insulin secretion; evanescent wave microscopy; PIP3; PKA; Epac; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. LÄS MER

  3. 2. Signaling capacity of ß2-integrins in relations to neutrophil motility

    Författare :Ragnhild Löfgren; Linköpings universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; INTERDISCIPLINARY RESEARCH AREAS; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN;

    Sammanfattning : The neutrophil granulocyte is one of the most mobile cell types in the human body and represents the first line of defense against invading pathogens. Adhesion and chemotactic receptors on the cell surface work together through modulations of the cytoskeleton and thereby cause the cell to move. LÄS MER

  4. 3. Roles of PI3-kinase and ARAP2 in regulating glucose metabolism

    Författare :Aditi Chaudhari; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PI3-kinase; Type 2 diabetes; ARAP2; Lipid droplets; metabolism;

    Sammanfattning : Insulin signaling is mediated by a complex, highly integrated network which functions to control multiple metabolic and growth processes throughout the organism. A key enzyme in the insulin signaling network is phosphatidylinositol 3-kinase (PI3-kinase). LÄS MER

  5. 4. Cyclic AMP Oscillations in Insulin-Secreting Cells

    Författare :Jenny Sågetorp; Anders Tengholm; Erik Gylfe; Lena Stenson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : Cyclic AMP is an intracellular messenger that regulates numerous processes in various types of cells. In pancreatic β-cells, cAMP potentiates the secretion of insulin by promoting Ca2+ signals and by amplifying Ca2+-triggered exocytosis. Whereas Ca2+ signals have been extensively characterized, little is known about the kinetics of cAMP signals. LÄS MER

  7. 5. Commensal microbes, immune reactivity and childhood inflammatory bowel disease

    Författare :Cecilia Barkman; Göteborgs universitet; []
    Nyckelord :Inflammatory bowel disease; IBD; Pediatric; Childhood; Microbiota; T cells; B cells; cytokine; IL-12; monocytes; phagocytosis; intracellular signaling pathway; Crohn s disease; ulcerative colitis; children; flora;

    Sammanfattning : Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation of unknown etiology, but immune activation by the commensal microbiota probably plays a major role. The two major categories of IBD are ulcerative colitis and Crohn’s disease. LÄS MER