Sökning: "JNK"

Visar resultat 1 - 5 av 93 avhandlingar innehållade ordet JNK.

  1. 1. JNK/c-Jun Signaling and Peripheral Nerve Regeneration

    Författare :Charlotta Lindwall; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neuropsykologi; neurofysiologi; neurophysiology; Neurologi; neuropsychology; Neurology; Djurfysiologi; Animal physiology; JNK; signal transduction; nerve regeneration;

    Sammanfattning : The events associated with axonal injury in the peripheral nervous system (PNS) have been described in detail. However, the molecular mechanisms underlying the regenerative response, or neuronal cell death, following axonal injury are poorly understood. LÄS MER

  2. 2. MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death

    Författare :Dariush Mokhtari; Nils Welsh; Michael Welsh; Anders Tengholm; Shanta Persaud; Uppsala universitet; []
    Nyckelord :Cell biology; MEKK-1; JNK; human islets; β-cells; siRNA; apoptosis; cell death; MAPK; nitric oxide; cytokines; streptozotocin; c-Rel; NF-κB; Cellbiologi;

    Sammanfattning : Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. LÄS MER

  3. 3. Communicate or die : signalling in Drosophila immunity

    Författare :Karin Borge-Renberg; Dan Hultmark; Michéle Crozatier; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila; innate immunity; PGRP-LC; pattern recognition; JNK; antimicrobial peptides; Molecular biology; Molekylärbiologi;

    Sammanfattning : In general the work behind this thesis has revolved around the interesting pattern recognition gene family PGRPs (peptidoglycan recognition proteins). In particular the transmembrane PGRP-LC and to investigate its multifaceted role in the immune response of the fruit fly. LÄS MER

  4. 4. Vascular and metabolic effects of selective PDE-5 inhibition - clinical and experimental studies

    Författare :Lovisa Sjögren; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; MAPK; phosphodiesterase-5 inhibition; JNK; endothelial cells; E-selectine; VCAM-1; HUVEC; TNFa; ICAM-1; inflammation;

    Sammanfattning : ABSTRACT Vascular and metabolic effects of selective PDE-5 inhibition Clinical and experimental studies Lovisa Sjögren Department of Molecular and Clinical Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg Key words: Type 2 diabetes, phosphodiesterase-5 inhibition, inflammation, endothelial cells, HUVEC. TNFα, ICAM-1, VCAM-1, E-Selectin, JNK, MAPK Background: Type 2 diabetes (T2D) patients show impaired glucose metabolism, endothelial dysfunction, chronic low-grade inflammation as well as an increased risk of cardiovascular disease. LÄS MER

  5. 5. Host-pathogen interactions between Francisella tularensis and Drosophila melanogaster

    Författare :Malin Vonkavaara; Svenja Stöven; Ingrid Faye; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; arthropod vector; JNK; lipopolysaccharide; antimicrobial peptides; Clinical Bacteriology; klinisk bakteriologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Francisella tularensis is a highly virulent Gram-negative bacterium causing the zoonotic disease tularemia. Arthropod-borne transmission plays an important role in transferring the disease to humans. F. LÄS MER