Sökning: "Allopregnanolone"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet Allopregnanolone.

  1. 1. Allopregnanolone and mood : studies of postmenopausal women during treatment with progesterone

    Författare :Lotta Andréen; Torbjörn Bäckström; Viveca Odlind; Umeå universitet; []
    Nyckelord :Obstetrics and gynaecology; Progesterone; Allopregnanolone; GABA; mood; bimodal; Obstetrik och kvinnosjukdomar;

    Sammanfattning : Introduction. Allopregnanolone and pregnanolone (neuroactive metabolites of progesterone) act as positive modulators of the GABAA receptor system which is the major inhibitory system in CNS. Contradictory results on the effect of GABAA receptor modulators are reported. LÄS MER

  3. 2. Allopregnanolone effects in women : clinical studies in relation to the menstrual cycle, premenstrual dysphoric disorder and oral contraceptive use

    Författare :Erika Timby; Marie Bixo; Torbjörn Bäckström; Anna-Carin N Wihlbäck; C Neill Epperson; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; GABAA receptor; menstrual cycle; premenstrual dysphoric disorder; saccadic eye velocity; oral contraceptives; hypothalamic amenorrhea;

    Sammanfattning : Background: Premenstrual dysphoric disorder (PMDD) affects 3–8% of women in fertile ages. Combined oral contraceptives (OCs) are widely used and some users experience adverse mood effects. The cyclicity of PMDD symptoms coincides with increased endogenous levels of allopregnanolone after ovulation. LÄS MER

  4. 3. Allopregnanolone effects on food intake and weight gain

    Författare :Ellinor Holmberg; Torbjörn Bäckström; Bo Söderpalm; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; allopregnanolone; neurosteroid; GABA; GABAA receptor; food intake; weight gain; obesity; hyperphagia; diurnal rhythm; schedule feeding; high fat diet; electrophysiology; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Background Obesity is currently one of the major causes of ill health and it is clear that overeatingis the cause of obesity. However, the actions of many endogenous factors that contribute to overeating are still not well understood. LÄS MER

  5. 4. Tolerance and antagonism to allopregnanolone effects in the rat CNS

    Författare :Sahruh Turkmen; Inga-Maj Johansson; Agneta Nordberg; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; GABA-A receptor; UC1011; Spatial memory; Morris Water Maze; Tolerance; Silent second; mRNA; Obstetrics and gynaecology; Obstetrik och gynekologi;

    Sammanfattning : Many studies have suggested a relationship between sex steroids and negative mental and mood changes in women. Allopregnanolone, a potent endogenous ligand of the GABA-A receptor and a metabolite of progesterone, is one of the most accused neuroactive steroids. LÄS MER

  7. 5. Stress steroids as accelerators of Alzheimer's disease. : Effects of chronically elevated levels of allopregnanolone in transgenic AD models

    Författare :Sara Bengtsson; Mingde Wang; Torbjörn Bäckström; Maja Johansson; Caroline Graff; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; Alzheimer s disease; beta-amyloid; synaptophysin; chronic stress; Morris water maze; obstetrik och gynekologi; Obstetrics and Gynaecology; medicinsk farmakologi; Medical Pharmacology; Neurology; neurologi; Geriatrics; geriatrik; medical behavioral science; medicinsk beteendevetenskap;

    Sammanfattning : Background Alzheimer’s disease (AD) and dementia are devastating con­ditions not only for the affected patients but also for their families.  The economical costs for the society are tremendous. LÄS MER