Sökning: "AMPA"

Visar resultat 11 - 15 av 56 avhandlingar innehållade ordet AMPA.

1. 11. Circadian rhythm dysfunction in the suprachiasmatic nucleus : effects of Trypanosoma brucei brucei infection and inflammatory cytokines

   Författare :Gabriella B Lundkvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Suprachiasmatic nucleus; slice; Trypanosoma brucei; sleeping sickness; spontaneous firing; rhytm; synaptic activity; GABA; glutamate; AMPA cytokines; sleep regulation; interferon-gamma; tumor necrosis factor-alpha;

   Sammanfattning : Alterations in the mammalian circadian pacemaker, the hypothalamic suprachiasmatic nuclei (SCN), were studied in an experimental rat model of African trypanosomiasis, or sleeping sickness, caused by infections with subspecies of Trypanosoma brucei (T b). Characteristic signs of the disease are marked disturbances in circadian rhythms, such as a fragmentation of the sleep-wake cycle. LÄS MER

3. 12. The central cervical nucleus in the rat : studies on connectivity, function and chemical transmission

   Författare :Birger Ragnarson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Amino acid transmitter AMPA Anterograde Cerebellum Cervical Choleragenoid Electron microscopy Freeze-substitution Glutamate Horseradish peroxidase Ia primary afferent Immunogold Immunocytochemistry Locomotion Motoneuron NMDA Neck muscle Postembedding;

   Sammanfattning : The central cervical nucleus (CCN) is a spinocerebellar cell group in the upper cervical spinal cord (rat: Cl-C3), that is known to receive a powerful primary afferent input from, the upper cervical spinal nerves (C 1-C4), originating mainly from muscle spindle afferents in deep dorsal neck muscles and from the ipsi- and contralateral vestibular nuclei. It projects to the cerebellar vermis bilaterally and to all the vestibular nuclei contralaterally. LÄS MER

4. 13. Plasticity of the developing glutamate synapse in the hippocampus

   Författare :Therése Abrahamsson; Göteborgs universitet; []
   Nyckelord :synaptic plasticity; long-term potentiation; short-term potentiation; silent synapse; development; hippocampus; glutamate;

   Sammanfattning : Synapses are highly plastic, i.e. they have the ability to change their signaling strength both in the short- and long-term (e.g. LÄS MER

5. 14. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

   Författare :Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

   Sammanfattning : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. LÄS MER

7. 15. K+ channels and the regulation of synaptic transmission

   Författare :Evanthia Nanou; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neuronal excitability is highly regulated by K+ channels that are activated by a voltage change across the plasma membrane or by a rise in intracellular Na+ or Ca2+ concentration. The main focus of this thesis has been to characterize the Na+-activated K+ (KNa) and the Ca2+-activated K+ (KCa) channels and to determine their role in regulating synaptic transmission in the lamprey spinal cord. LÄS MER