Sökning: "Aβ 1-42"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Aβ 1-42.

1. 1. Cellular Uptake of Amyloid Forming Proteins Related to Neurodegenerative Disease

   Författare :Emelie Vilhelmsson Wesén; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aβ 1-40 ; flow cytometry; confocal microscopy; SH-SY5Y; fluorescence; Aβ 1-42 ; Alzheimer’s disease; amyloid fibril; α-synuclein; amyloid-β;

   Sammanfattning : Aggregation and deposition of disease-associated protein is a pathological hallmark of several human disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). These diseases are characterized by the formation of amyloid-β (Aβ) and α-synuclein (α-syn) amyloid fibrils, in extracellular and intracellular locations, respectively. LÄS MER

3. 2. Amyloid Proteins in Neurodegenerative Disease – Role of Extrinsic Modifiers

   Författare :Nima Sasanian; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Sammanfattning : ABSTRACT Self-assembly of disease-associated proteins into fibrillar homopolymers, so-called “amyloid fibrils” is a pathological hallmark of several debilitating human disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). AD and PD are associated with the formation of amyloid fibrils from the proteins amyloid-β (Aβ) and α-syn (α-syn), in the extracellular and intracellular space, respectively. LÄS MER

4. 3. Using CSF biomarkers to understand mechanisms of behavioral changes and effects of drug treatment in dementia

   Författare :Victor Bloniecki Kallio; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Dementia is affecting millions of people around the world, and the global prevalence will continuously rise. Neuropsychiatric symptoms (NPS) in dementia are frequent and constitute a key driving force in the disease burden for both patients, families, caregivers and society. LÄS MER

5. 4. Theoretical Studies of Protein-Ligand Interactions

   Författare :Kuang Guanglin; Tu Yaoquan; Bulone Vincent; David van der Spoel; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Binding free energy; molecular dynamics; molecular docking; metadynamics; nicotinic receptor; amyloid fibril; PH domain; Theoretical Chemistry and Biology; Teoretisk kemi och biologi;

   Sammanfattning : The protein-ligand interaction is an important issue in rational drug design and protein function research. This thesis focuses on the study of protein-ligand interactions using various molecular modeling methods, which are used in combination to predict the binding modes and calculate the binding free energies of several important protein-ligand systems, as summarized below. LÄS MER

7. 5. Development of the Amyloid Fibril Characterisation Toolbox - New use for old dyes

   Författare :David Lindberg; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Amyloid-β; Thioflavin-T; Fluorescence spectroscopy; YOYO-1; Amyloid fibrils; Linear dichroism; Alzheimer’s disease;

   Sammanfattning : Amyloid fibrils are self-assembled protein homopolymers that playcentral roles in the pathology of several human diseases, most notably in progressiveneurodegenerative diseases such as Alzheimer’s disease (AD). In AD, fibrils areformed by the amyloid-β (Aβ) peptide, an enzymatic cleavage product that is naturallyproduced in human brain tissue. LÄS MER