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1. 1. Chemical and stimulus-induced NMDA-dependent plasticity and the possible involved mechanisms

   Författare :Rui Li; Göteborgs universitet; []
   Nyckelord :synaptic plasticity; hippocampus; LTP; LTD; AMPA; NMDA; NR2A; NR2B;

   Sammanfattning : Long-term potentiation (LTP) and long-term depression (LTD) are considered as the most important forms of synaptic plasticity involved in learning and memory. The traditional way to induce LTP and LTD is by electric stimulation leading to activation of NMDA-R. LÄS MER

3. 2. Differences in glutamatergic transmission onto interneurons and pyramidal cells in the rat hippocampus

   Författare :Ilse Riebe; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AMPA; development; glutamate transmission; hippocampus; interneuron; NMDA; synapse;

   Sammanfattning : In the human brain there are about 100 billion excitatory glutamatergic neurons and 10 billion inhibitory GABAergic neurons. During development, these neurons are synaptically wired together into neural networks, functionally prepared to perform the full register of brain functions, and to learn from experiences. LÄS MER

4. 3. Activity-dependent changes of synaptic transmission in a long-term perspective and processes involved

   Författare :Mikhail Dozmorov; Göteborgs universitet; []
   Nyckelord :synaptic plasticity; hippocampus; LTP; LTD; AMPA; NMDA; protein synthesis;

   Sammanfattning : Synaptic plasticity is an essential property of the central nervous system. It is thought torepresent a mechanism for memory aquisition, storage and recall. The most well studied forms ofsynaptic plasticity are homosynaptic NMDAR-dependent LTP and LTD in the hippocampus inducedby specific patterns of electrical stimulation. LÄS MER

5. 4. Short- and long-term neuronal plasticity in hippocampal CA1 region of rat

   Författare :Fen-Sheng Huang; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glutamate; hippocampus; plasticity; synapse; LTP; LTD; AMPA; NMDA;

   Sammanfattning : The brain is highly plastic, displaying both short- and long-term changes, resulting from developmental processes as well as learning and memory. Moreover, short-term plasticity such as paired pulse facilitation and depression (PPF, PPD) have long been used to monitor the presynaptic versus postsynaptic changes occurring during more lasting processes such as long-term potentiation and depression (LTP, LTD). LÄS MER

7. 5. Plasticity and variation of synaptic responses in hippocampus. Role of AMPA and NMDA receptors

   Författare :Yin-Ping Niu; Göteborgs universitet; []
   Nyckelord :learning and memory; synaptic plasticity; hippocampus; synapse; AMPA receptor; NMDA receptor; LTP; LTD; CV; TFS;

   Sammanfattning : It is generally believed that synaptic plasticity in the central nervous system may underlie learning and memory as well as neuronal development. The most wellstudied examples of such synaptic plasticity are long-term potentiation (LTP) andlong-term depression (LTD). LÄS MER