Sökning: "zinc finger protein"

Visar resultat 21 - 25 av 47 avhandlingar innehållade orden zinc finger protein.

  1. 21. A genetic approach to the identification of new components regulating development in Arabidopsis thaliana

    Författare :Ingela Fridborg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; fysiologisk botanik; Physiological Botany;

    Sammanfattning : Two new genes involved in important processes of plant development were identified in the model plant Arabidopsis thaliana. The genes were isolated from mutants generated through insertional mutagenesis based on a transposon tagging approach. LÄS MER

  3. 22. The p53-induced gene wig-1 : regulation of expression and role in embryonic development

    Författare :Margareta Wilhelm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The p53 tumor suppressor is a transcription factor that responds to various forms of cellular stress. Activated p53 induces growth arrest or apoptosis through transcriptional regulation of a wide range of target genes. More than 50% of human tumors carry mutations in the p53 gene, most of which reside within the DNAbinding core domain of p53. LÄS MER

  4. 23. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity

    Författare :Emelie Svensson; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; Cytologi; cancerology; oncology; Cytology; Medicin människa och djur ; Medicine human and vertebrates ; Cofilin 1; NDRG2; IRF-8; BCR ABL1; hematopoiesis; Wilms´ tumor gene 1; leukemia;

    Sammanfattning : The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. LÄS MER

  5. 24. Molecular mechanisms involved in the growth of human uterine leiomyomas

    Författare :Xuxia Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human uterine leiomyomas; myometrium; the menstrual cycle; estrogen; progesterone; cellular proliferation; apoptosis; oncogene; growth factor; growth factor receptor.;

    Sammanfattning : Human uterine leiomyomas (fibroids) are benign neoplasms arising from uterine smooth muscle cells, and are suggested to be sex steroid dependent. The aim of this study was to investigate the molecular mechanisms by which sex steroids, mainly estrogen and progesterone, influence the growth of Ieiomyomas. LÄS MER

  7. 25. Pathophysiological impact of targeting the ROS-p53 axis

    Författare :Volkan I. Sayin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antioxidants; Cancer; p53; ROS; atherosclerosis;

    Sammanfattning : The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using molecular biology and biochemical techniques together with mouse genetics and bioinformatics. LÄS MER