Sökning: "Cofilin 1"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Cofilin 1.

  1. 1. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity

    Författare :Emelie Svensson; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; Cytologi; cancerology; oncology; Cytology; Medicin människa och djur ; Medicine human and vertebrates ; Cofilin 1; NDRG2; IRF-8; BCR ABL1; hematopoiesis; Wilms´ tumor gene 1; leukemia;

    Sammanfattning : The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. LÄS MER

  3. 2. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer disease

    Författare :Zhi Tang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : An important neurophathological hallmark of Alzheimer disease (AD) is the progressive formation of neurofibrillary tangles composed of aberrant hyperphosphorylated tau aggregates. Evidence from human postmortem AD brains and in vitro and in vivo rapamycin-treated drug models implicated an abnormal accumulation of the mammalian target of rapamycin (mTor) in AD brains. LÄS MER

  4. 3. Restricted antigen recognition in B cell chronic lymphocytic leukemia

    Författare :Anna Lanemo Myhrinder; Anders Rosén; Linköpings universitet; []
    Nyckelord :Chronic lymphocytic leukemia; auto antigens; CLL cell lines; MEDICINE; MEDICIN;

    Sammanfattning : Chronic lymphocytic leukemia (CLL) cells are considered to be derived from antigen-exposed B cells. To further explore the antigen-driven selection behind the leukemogenesis of CLL, we performed immunoglobulin (Ig) specificity screening of 7 CLL cell lines and 23 primary CLL clones from patient peripheral blood. LÄS MER

  5. 4. The many faces of p57Kip2 : acting in apoptosis, differentiation and cytoskeleton reorganisation

    Författare :Pinelopi Vlachos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : p57Kip2 is a known cyclin dependent kinase inhibitor, which has been suggested to be a tumor suppressor gene. Indeed various human cancers show a reduction in p57Kip2 expression, indicating that this protein might be of relevance in tumorigenesis. LÄS MER

  7. 5. Actin and myosin in transcriptional and post-transcriptional control of gene expression

    Författare :Ales Obrdlik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Actin plays a key role in basal gene regulation. In the past decade actin has been found to be a component of chromatin remodeling complexes, ribonucleoprotein particles and to associate with all eukaryotic RNA polymerases. LÄS MER