Sökning: "NDRG2"

Hittade 2 avhandlingar innehållade ordet NDRG2.

1. 1. WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?

   Författare :Karina Vidovic; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; WT1 delZ ; leukemia; BCR ABL1; hematopoiesis; NDRG2; IRF8; WT1;

   Sammanfattning : Wilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. LÄS MER

3. 2. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity

   Författare :Emelie Svensson; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; Cytologi; cancerology; oncology; Cytology; Medicin människa och djur ; Medicine human and vertebrates ; Cofilin 1; NDRG2; IRF-8; BCR ABL1; hematopoiesis; Wilms´ tumor gene 1; leukemia;

   Sammanfattning : The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. LÄS MER