Sökning: "tumor suppressor gene"

Visar resultat 26 - 30 av 231 avhandlingar innehållade orden tumor suppressor gene.

1. 26. Mutational analyses of the tumor suppressor gene Patched1 : role in non-melanoma skin cancer and nevoid basal cell carcinoma

   Författare :Erika Lindström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Skin cancer is the most common cancer in Western countries, with a rapidly increasing incidence. The majority of these tumors are non-melanoma skin cancer (NMSC). The most common NMSC is basal cell carcinoma (BCC) followed by squamous cell carcinoma (SCC). In the US more than 1. LÄS MER

3. 27. Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3

   Författare :Hajnalka Kiss; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Elimination test; common eliminated region 1 CER1 ; 3p21.3; tumor suppressor gene; large scale sequencing; LIMD1; LZTFL1; FYC01; TMEM7; LRRC2; LUZP3.;

   Sammanfattning : An experimental system, called the elimination test (Et), was developed to identify tumor growth antagonizing genes. Chromosome 3 containing microcell hybrids (MCHs) were passaged through SCID mice and regular deletion of the short arm of chromosome 3 (3p) were found by cytogenetic and molecular methods. LÄS MER

4. 28. Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53

   Författare :Meiqiongzi Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows evasion of cell death and rapid tumor progression. LÄS MER

5. 29. Functional studies of the multiple endocrine neoplasia type 1 gene

   Författare :Lovisa Bylund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MEN1; menin; tumor suppressor gene; cancer; RNAi; promoter; expression; cytogenetic; microarray;

   Sammanfattning : The multiple endocrine neoplasia type 1 (MEN1, OMIM 131 100) syndrome is an autosomal dominant trait with a near 100% penetrance and with an estimated prevalence of 2-20/100 000. The syndrome is characterized by neoplasia affecting the parathyroid glands (90-97%), enteropancreatic endocrine tissues (30-80%) and the anterior pituitary gland (15-50%) but tumors arc also found in other, both endocrine and non endocrine tissues. LÄS MER

7. 30. Molecular mechanisms of tumor development in hyperparathyroidism

   Författare :Filip Farnebo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :parathyroid; hyperparathyroidism; MEN 1; FIHP; loss of heterozygosity; comparative genomic hybridization; mutation analysis; in situ hybridization;

   Sammanfattning : Loss of heterozygosity (LOH) analysis and comparative genomic hybridization (CGH) were used in an attempt to identify recurrent chromosomal alterations in different types of parathyroid tumors. These included familial and sporadic, benign and malignant, as well as primary, irradiation associated and secondary tumors. LÄS MER