Sökning: "tumor suppressor gene"

Visar resultat 21 - 25 av 231 avhandlingar innehållade orden tumor suppressor gene.

1. 21. War and peace in the tumor microenvironment : tumor-associated cells as facilitators or adversaries during tumor development

   Författare :Margarita Bartish; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The tumor microenvironment, including immune cells, fibroblasts and vasculature, profoundly affects tumor development by initially opposing, but eventually facilitating tumor growth, vascularization and spread. Though corrupted by the growing tumor, such cells remain non-transformed and thus, with proper cues, are possible to direct toward their physiological anti-tumor function. LÄS MER

3. 22. Delection mapping of human 3p in major epithelial types of cancer and fine localization of candidate tumor suppressor genes

   Författare :Jian Liu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Tumor suppressor gene; epithelial carcinoma; human chromosome 3p;

   Sammanfattning : Allele loss and deletion mapping using microsatellite markers and the detection of homozygous deletions represented until now the most powerful method to localize potential TSGs. Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of renal cell carcinoma (RCC), small (SCLCs) and more than 90% of non-small (NSCLC) cell lung cancers. LÄS MER

4. 23. Exploring novel roles of tumor pericytes

   Författare :Jong Wook Hong; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tumor biology has been extensively studied over the last few decades, with a principal focus on how neoplastic cells obtain cellular immortality. A number of oncogenes and tumor suppressor genes have been uncovered that regulate cancerous transformation. LÄS MER

5. 24. Functional studies of Wilms’ tumor gene 1 (WT1) in hematopoiesis and leukemia

   Författare :Helena Svedberg; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; K562; U937; CD34 ; leukemia; WT1; hematopoiesis; Hematologi; extracellulära vätskor;

   Sammanfattning : Wilms’ tumor gene 1 (WT1) is a zinc-finger transcription factor that is involved in the development of urogenital organs and mesothelial tissues. It was initially identified as a tumor suppressor gene, based on the observation that somatic inactivation of the gene predispose for development of the pediatric kidney cancer Wilms’ tumor. LÄS MER

7. 25. Gene Expression Patterns in a Rat Model of Human Endometrial Adenocarcinoma

   Författare :Sandra Karlsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rat; complex disease; Endometrial adenocarcinoma; gene expression profiling; cDNA microarrays; candidate genes; Molecular biology; Medical sciences;

   Sammanfattning : Endometrial cancer develops from the endometrium of the uterus and is the most common pelvic malignancy diagnosed in women in the western society. Similar to all cancer diseases, endometrial cancer is a disorder that results from complex patterns of genetic and epigenetic alterations involved in the malignant transformation. LÄS MER