Sökning: "tumor suppressor gene"
Visar resultat 31 - 35 av 231 avhandlingar innehållade orden tumor suppressor gene.
31. Application of Genomic and Expression Arrays for Identification of new Cancer Genes
Sammanfattning : Copy number variation (CNV) comprises a recently discovered kind of variation involving deletion and duplication of DNA segments of variable size, ranging from a few hundred basepairs to several million. By altering gene dosage levels or disrupting proximal or distant regulatory elements CNVs create human diversity. LÄS MER
32. Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors
Sammanfattning : Epigenetic modifications were shown to play an essential role in tumorigenesis. Epigenetic mechanisms can alter transcription in several ways, through DNA methylation and/or through histone modification. DNA methylation at the TSS (transcriptional start site) has been implicated in tumor development and gene silencing. LÄS MER
33. Enzymes involved in heparan sulfate chain elongation : Function of a novel family of tumor suppressors?
Sammanfattning : Heparan sulfate (HS) is a glycosaminoglycan associated with many physiological functions such as regulation of growth factor action and cell adhesion. The HS polysaccharide is synthesized by alternating addition of D-glucuronic acid (GlcA) and N-acetyl-D-glucosamine (GlcNAc) units from the corresponding UDP-sugar precursors. LÄS MER
34. Exploring the role of p73-isoforms during tumor development
Sammanfattning : The p73 gene was first discovered in 1997 as a family member of p53, and since then this gene has been studied extensively in cancer biology. Among its two main classes of isoforms, TAp73 acts as a tumor suppressor, while in contrast ΔNp73 was shown to act in a dominant negative fashion as an oncogene which opposes the functions of TAp73 and p53. LÄS MER
35. Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy
Sammanfattning : A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. LÄS MER