Sökning: "3p21.3"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet 3p21.3.

1. 1. Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3

   Författare :Hajnalka Kiss; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Elimination test; common eliminated region 1 CER1 ; 3p21.3; tumor suppressor gene; large scale sequencing; LIMD1; LZTFL1; FYC01; TMEM7; LRRC2; LUZP3.;

   Sammanfattning : An experimental system, called the elimination test (Et), was developed to identify tumor growth antagonizing genes. Chromosome 3 containing microcell hybrids (MCHs) were passaged through SCID mice and regular deletion of the short arm of chromosome 3 (3p) were found by cytogenetic and molecular methods. LÄS MER

3. 2. Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'

   Författare :Ying Yang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Elimination test; common eliminated region 1 CER1 ; 3p21.3; microcell hybrids; tumor suppressor gene; LF lactoferrin ; LIMD1 LIM-domain containing gene 1 ; sequencing; MMCT microcell mediated chromosome transfer ; real time PM methylation;

   Sammanfattning : The aim of elimination test (Et) is to identify tumor antagonizing genes from chromosome regions that are regularly deleted in microcell hybrid (MCH) derived tumors through serial SCID mice passages. Et so far was focused on the short arm of human chromosome 3 (chr 3) due to its frequent deletions in 21 tumor types including renal cell carcinoma (RCC), small cell lung carcinoma (SCLC) and breast cancer (BRC). LÄS MER

4. 3. A microcell hybrid based 'elimination test' in the search for malignancy related genes

   Författare :Stephan Imreh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This thesis is focused on the elimination test developed by us (Imreh et al, 1994). The elimination test was designed as a functional test for malignancy related gene identification. Its task is to follow the cytogenetic and molecular alterations on single normal chromosomes transferred into tumor cells. LÄS MER

5. 4. Delection mapping of human 3p in major epithelial types of cancer and fine localization of candidate tumor suppressor genes

   Författare :Jian Liu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Tumor suppressor gene; epithelial carcinoma; human chromosome 3p;

   Sammanfattning : Allele loss and deletion mapping using microsatellite markers and the detection of homozygous deletions represented until now the most powerful method to localize potential TSGs. Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of renal cell carcinoma (RCC), small (SCLCs) and more than 90% of non-small (NSCLC) cell lung cancers. LÄS MER

7. 5. Molecular genetics of hereditary non-polyposis colorectal cancer

   Författare :Pia Tannergård; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Colorectal cancer (CRC) is one of the most prevalent malignancies in the Western World and one of the most predominant causes of death by cancer. There is a subgroup of syndromes with a high incidence of CRC which is transmitted in an autosomal dominant fashion. LÄS MER