Sökning: "PEDF"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet PEDF.

1. 1. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

   Författare :Sofia Halin; Anders Bergh; Pernilla Wikström; Stina Rudolfsson; Carl-Henrik Heldin; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; Pathology; Patologi; patologi; Pathology;

   Sammanfattning : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. LÄS MER

3. 2. Regulation of Hematopoietic Stem Cells

   Författare :Emma Rörby; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; hematopoietic stem cells; hematopoietic stem cell expansion; cord blood; transforming growth factor beta; Smad signaling; pigment epithelium derived factor; CD9;

   Sammanfattning : This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate new HSCs. LÄS MER

4. 3. Inner ear proteomics and barriers : Clinical and experimental findings

   Författare :Jesper Edvardsson Rasmussen; Göran Laurell; Per Olof Eriksson; Helge Rask-Andersen; Jonas Bergquist; Måns Magnusson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vestibular schwannoma; Hearing loss; Inner ear; Proteome; Perilymph; Endolymph; Furosemide; NKCC1; Fetuin-A; Complement component factor-H realted protein 2; CFHR2; Inflammation; MRI; Oto-Rhino-Laryngology; Oto-rhino-laryngologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Hearing is important in many aspects of life, including communication, assessing one’s surroundings, entertainment and social interaction. Hearing loss is common and according to the Global Burden of Disease Study, 5% of the global population require hearing rehabilitation (1). LÄS MER

5. 4. Pathways that govern hematopoietic stem cell fate

   Författare :Matilda Billing; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :hematopoies; Hematopoietic stem cell; TGF beta; Smad signaling; GATA2; p57;

   Sammanfattning : Hematopoietic stem cells (HSCs) compose a rare population of undifferentiated cells, residing in the bone marrow of adult individuals, ensuring life-long maintenance and replenishment of the blood system. This fantastic achievement is possible owing to two special characteristics of the HSCs: their ability to make copies of themselves (self-renew), and their capacity to differentiate to all lineages of the blood system. LÄS MER

7. 5. Regulation of postnatal neurogenesis and brain angiogenesis by thyroid hormone

   Författare :Jenny Liqun Zhang; Göteborgs universitet; []
   Nyckelord :thyroid hormone; neurogenesis; angiogenesis; SVZ OB; hippocampus; neural stem cells; endothelial cells; astrocytes;

   Sammanfattning : Thyroid hormone (TH), which is secreted by the thyroid gland, exerts significant effects on the central nervous system (CNS), especially during development, so that delayed treatment of perinatal hypothyroidism results in severe cognitive retardation. Continuous postnatal neurogenesis occurs throughout adulthood in the subventricular zone (SVZ) of the lateral ventricle wall and in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampal formation. LÄS MER