Sökning: "Malin Sund"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Malin Sund.

  1. 1. Angiogenesis regulation in hormone dependent breast- and ovarian cancer

    Författare :Christina Bendrik; Charlotta Dabrosin; Malin Sund; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Angiogenesis is a key event in tumor progression and a rate-limiting step in the establishment of a clinical cancer disease. The net balance of pro- and anti-angiogenesis mediators in the tissue dictates the angiogenic phenotype of a tumor. LÄS MER

  2. 2. The Akt/mTOR Pathway and Estrogen Receptor Phosphorylations : a crosstalk with potential to predict tamoxifen resistance in breast cancer

    Författare :Josefine Bostner; Olle Stål; Cecilia Bivik; Malin Sund; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Estrogen receptor α content is the primary breast cancer biomarker distinguishing the patients responsive from the non-responsive to endocrine treatments. Tamoxifen is an estrogen competitor with large potential to treat breast cancer patients and prolongs time to recurrence. LÄS MER

  3. 3. Small Intestinal Neuroendocrine Tumours : Genetic and Epigenetic Studies and Novel Serum Biomarkers

    Författare :Katarina Edfeldt; Peter Stålberg; Per Hellman; Gunnar Westin; Malin Sund; Endokrinkirurgi; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; SI-NET; microarray; tumour suppressor gene; epigenetic; serum biomarkers; Kirurgi; Surgery;

    Sammanfattning : Small intestinal neuroendocrine tumours (SI-NETs) are rare, hormone producing and proliferate slowly. Patients usually display metastases at time of diagnosis, the tumours are difficult to cure, and the disease course is unpredictable. LÄS MER

  4. 4. Stromal components and micro-RNAs as biomarkers in pancreatic cancer

    Författare :Oskar Franklin; Malin Sund; Daniel Öhlund; Ola Billing; Marco Del Chiaro; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic cancer; stroma; basement membrane; tumour markers; type IV collagen; endostatin; osteopontin; tenascin c; hyaluronan; CD44; micro-RNA; kirurgi; Surgery;

    Sammanfattning : Background Pancreatic ductal adenocarcinoma (PDAC) patients have the poorest 5-year survival rates of all cancer forms. It is difficult to diagnose at early disease stages, tumour relapse after surgery is common, and current chemotherapies are ineffective. LÄS MER

  5. 5. Permanent stoma after anterior resection for rectal cancer : prevalence and mechanisms

    Författare :Klas Holmgren; Martin Rutegård; Jörgen Rutegård; Markku M. Haapamäki; Peter Matthiessen; Malin Sund; Per J. Nilsson; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rectal cancer; anterior resection; permanent stoma; defunctioning stoma; mesorectal excision; biomarkers; Surgery; kirurgi;

    Sammanfattning : While sphincter-saving surgery constitutes standard treatment for rectal cancer, anterior resection still harbours a significant risk of a permanent stoma in the long run. Although anastomotic leakage plays a major role in this surgical dilemma, the exact mechanisms are not known, while surveys indicate a stoma-free outcome is essential for a majority of patients. LÄS MER