Sökning: "PRRT"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet PRRT.

  1. 1. Therapy with 177Lu-octreotate - pharmacokinetics, dosimetry and kidney toxicity

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Maria Larsson; Göteborgs universitet.; Gothenburg University.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRRT; 177Lu-octreotate; 111In-octreotide; dosimetry; biokinetics; scintigraphy; conjugate view method; renal function; renal toxicity; lysine; DMSA; 99mTc-DTPA; 99mTc-DMSA;

    Sammanfattning : 177Lu-octreotate is used for treatment of patients with somatostatin receptor expressing neuroendocrine tumors in some clinics using a standard schedule. Renal and bone marrow toxicity are the main limiting factors. LÄS MER

  2. 2. Biomarker discovery and assessment for prediction of kidney response after 177Lu-octreotate therapy

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Emil Schüler; Göteborgs universitet.; Gothenburg University.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRRT; somatostatin; radionuclide therapy; 177Lu-octreotate; scintigraphy; renal function; toxicity; kidney response; radiation biology; microarray; molecular biomarkers; ionizing radiation; miRNA; proteomics; transcriptional response;

    Sammanfattning : Patients suffering from neuroendocrine tumors are oftentimes presented with spread disease at the time of diagnosis. Therapy using somatostatin analogs is today the only potentially curative treatment option for these patients. LÄS MER

  3. 3. Lutetium-177-octreotate treatment of small intestine neuroendocrine tumors - Radiation biology as basis for optimization

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Johan Spetz; Göteborgs universitet.; Gothenburg University.; Göteborgs universitet.; Gothenburg University.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide receptor radionuclide therapy; PRRT; somatostatin receptors; SSTR; midgut carcinoid; radiogenomics;

    Sammanfattning : Patients with neuroendocrine tumors (NETs) often have metastatic spread at the time of diagnosis. NETs frequently express somatostatin receptors (SSTR) that can be targeted by radiolabeled somatostatin analogs (e.g. 177Lu-octreotate). LÄS MER

  4. 4. A1M as a Radioprotector of the Kidneys

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Jonas Ahlstedt; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radioprotection; PRRT; cancer; A1m;

    Sammanfattning : .... LÄS MER

  5. 5. Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Anna-Karin Elf; Göteborgs universitet.; Gothenburg University.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroendocrine tumour; peptide receptor radionuclide therapy; somatostatin receptor 2 expression; radiosensitization; radioembolization; diffusion weighted imaging;

    Sammanfattning : ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often tumour control of NETs, but rarely cure. LÄS MER