Sökning: "theranostics"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet theranostics.

1. 1. Prostate cancer theranostics using GRPR antagonist RM26

   Författare :Bogdan Mitran; Anna Orlova; Vladimir Tolmachev; Ulrika Rosenström; Tony Lahoutte; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastrin-releasing peptide receptor GRPR ; Bombesin; Prostate-specific membrane antigen PSMA ; Antagonist; Radionuclide molecular imaging; Theranostics; Peptide receptor radionuclide therapy PRRT .;

   Sammanfattning : The malignant transformation of cells is often associated with an alteration of their molecular phenotype, resulting in overexpression of several cell surface proteins. Gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) are examples of such pro-teins that are expressed at a high density in prostate cancer. LÄS MER

3. 2. Affibody Molecules for HER3-targeted Theranostics of Malignant Tumours

   Författare :Maria Rosestedt; Anna Orlova; Vladimir Tolmachev; Olof Eriksson; Sten Nilsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affibody molecules; theranostics; HER3; molecular imaging;

   Sammanfattning : The HER3 receptor plays a strong role in disease progression and resistance to therapies in several cancer types. Due to its endogenous expression and low overexpression in malignant tumours, it is a particularly challenging target. LÄS MER

4. 3. Theranostics in Neuroendocrine Tumors : Somatostatin Receptor Imaging and Therapy

   Författare :Ezgi Ilan; Mark Lubberink; Peter Bernhardt; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 177Lu-DOTATATE; 68Ga-DOTATATE; 68Ga-DOTATOC; PRRT; Theranostics; PET CT; SPECT CT; Neuroendocrine tumors; Somatostatin receptors; Medicinsk radiofysik; Medical Radiophysics;

   Sammanfattning : Neuroendocrine tumors (NETs) are characterized by cellular overexpression of somatostatin receptors (SSTR), which allows for the use of radiolabeled somatostatin analogs (SSA) for both imaging and therapy. Because NETs often are diagnosed at a metastatic stage, curative surgery is not possible. LÄS MER

5. 4. Synthesis and application of β-configured [18/19F]FDGs : Novel prosthetic CuAAC click chemistry fluoroglycosylation tools for amyloid PET imaging and cancer theranostics

   Författare :Mathias Elgland; Peter Konradsson; Peter Nilsson; Per Hammarström; Olof Solin; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; FDG; clickable; PET; synthesis; in vivo imaging; theranostics;

   Sammanfattning : Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. LÄS MER

7. 5. Theranostic Targeting of GRPR and PSMA in Prostate Cancer

   Författare :Ayman Abouzayed; Anna Orlova; Ulrika Rosenström; Anzhelika Vorobyeva; Bogdan Mitran; Cristina Müller; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; gastrin-releasing peptide receptor GRPR ; prostate-specific membrane antigen PSMA ; nuclear medicine; molecular imaging; radiotracers; theranostics; Farmaceutisk vetenskap; Pharmaceutical Science; Oncology; Onkologi;

   Sammanfattning : This thesis is based on five original articles that investigated the theranostics of prostate cancer by gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) targeting. GRPR and PSMA are two extensively evaluated prostate cancer cell markers due to their overexpression in the majority of prostate cancer samples. LÄS MER