Sökning: "transmembrane helices"
Visar resultat 11 - 15 av 32 avhandlingar innehållade orden transmembrane helices.
11. Membrane-bound proteins : Characterization, evolution, and functional analysis
Sammanfattning : Alpha-helical transmembrane proteins are important components of many essential cell processes including signal transduction, transport of molecules across membranes, protein and membrane trafficking, and structural and adhesion activities, amongst others. Their involvement in critical networks makes them the focus of interest in investigating disease pathways, as candidate drug targets, and in evolutionary analyses to identify homologous protein families and possible functional activities. LÄS MER
12. Prokaryotic Arsenic Resistance - Studies in Bacillus subtilis
Sammanfattning : Arsenic is a toxic metalloid which is found all over the globe. Due to its toxicity and wide abundance, all living organisms have evolved intrinsic arsenic resistance systems. In this study, three proteins that provide arsenic resistance in the Gram-positive bacterium Bacillus subtilis have been investigated. LÄS MER
13. Integration and topology of membrane proteins
Sammanfattning : Membrane proteins comprise around 20-30% of most proteomes. They play important roles in most biochemical pathways. All receptors and ion channels are membrane proteins, which make them attractive targets for drug design. Membrane proteins insert and fold co-translationally into the endoplasmic reticular membrane of eukaryotic cells. LÄS MER
14. Sequence-based predictions of membrane-protein topology, homology and insertion
Sammanfattning : Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide variety of biochemical pathways. Apart from their general biological significance, membrane proteins are of particular interest to the pharmaceutical industry, being targets for more than half of all available drugs. LÄS MER
15. Generation and exploitation of proton motive force: Biochemical and structural analysis of three bacterial integral membrane proteins
Sammanfattning : Proton motive force, a necessity for all living cells, is generated and exploited by asignificant number of membrane-bound enzymes and transporters. The focus of thisthesis was to understand the physiological relevance, structure and mechanism of threesuch bacterial enzymes: proteorhodopsin; transhydrogenase; and AcrB. LÄS MER
