Sökning: "topology prediction"
Visar resultat 1 - 5 av 38 avhandlingar innehållade orden topology prediction.
1. Transmembrane Proteins and Protein Structure Prediction : What we can learn from Computational Methods
Sammanfattning : A protein’s 3D-structure is essential to understand how proteins function and interact and how biochemical processes proceed in organic life. Despite the advancement in experimental methods, it remains expensive and time-consuming to determine protein structure experimentally. LÄS MER
2. Topology Prediction of Membrane Proteins: Why, How and When?
Sammanfattning : Membrane proteins are of broad interest since they constitute a large fraction of the proteome in all organisms, up to 20-30%. They play a crucial role in many cellular processes mediating information flow and molecular transport across otherwise nearly impermeable membranes. LÄS MER
3. Formalizing life : Towards an improved understanding of the sequence-structure relationship in alpha-helical transmembrane proteins
Sammanfattning : Genes coding for alpha-helical transmembrane proteins constitute roughly 25% of the total number of genes in a typical organism. As these proteins are vital parts of many biological processes, an improved understanding of them is important for achieving a better understanding of the mechanisms that constitute life. LÄS MER
4. Application of membrane protein topology prediction
Sammanfattning : Membrane proteins often have essential functions in the cell and many are important drug targets, yet only a small fraction of available protein structures are of membrane proteins. Experimental techniques for elucidating membrane protein structures have proven laborious and expensive, opening the field for comparatively inexpensive computational modeling. LÄS MER
5. Sequence-based predictions of membrane-protein topology, homology and insertion
Sammanfattning : Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide variety of biochemical pathways. Apart from their general biological significance, membrane proteins are of particular interest to the pharmaceutical industry, being targets for more than half of all available drugs. LÄS MER