Sökning: "arsenic resistance"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden arsenic resistance.

  1. 1. Prokaryotic Arsenic Resistance - Studies in Bacillus subtilis

    Författare :Emil Aaltonen; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ArsB; Bacillus subtilis; arsenic resistance; arsenate reduction; arsenite transport; gene regulation; arsenate; ArsR; arsenite; transmembrane topology; Acr3; ArsK;

    Sammanfattning : Arsenic is a toxic metalloid which is found all over the globe. Due to its toxicity and wide abundance, all living organisms have evolved intrinsic arsenic resistance systems. In this study, three proteins that provide arsenic resistance in the Gram-positive bacterium Bacillus subtilis have been investigated. LÄS MER

  3. 2. Arsenic-induced protein aggregation and toxicity in Saccharomyces cerevisiae

    Författare :Sansan Hua; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Arsenic; Protein aggregation; Protein quality control; Yeast;

    Sammanfattning : Arsenic is prevalent in the environment and this toxic metalloid poses a substantial threat to human health with 100-200 million people worldwide estimated to be at risk. Chronic exposure to arsenic is associated with neurodegenerative and age-related disorders that are characterized by the accumulation of protein aggregates, including Parkinson’s and Alzheimer’s disease. LÄS MER

  4. 3. Effects of arsenic trioxide and hypoxia in multidrug-resistant neuroblastoma

    Författare :Jenny Karlsson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; neuroblastoma; multidrug resistance; hypoxia; glucose-deficiency; cell death; Bax; Apoptosis; arsenic trioxide;

    Sammanfattning : Neuroblastoma is a childhood tumour derived from the sympathetic nervous system. Although most children with neuroblastoma initially respond to treatment, approximately 50% of these patients relapse with multidrug-resistant tumours. Arsenic trioxide (As2O3) has been used for centuries to treat different clinical disorders including malignancies. LÄS MER

  5. 4. Approaches to Treatment of Children with Advanced Neuroblastoma

    Författare :Ingrid Øra; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; drug resistance; hypoxia; apoptosis; arsenic trioxide; treatment; diagnosis; neuroblastoma; sympathetic nervous system; Pediatri; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : Children with advanced neuroblastoma are at high risk for relapse of multidrug resistant disease, despite initial response to intensive multimodality treatment. Neuroblastomas have similarities with immature neuroblasts seen during embryonic development of the sympathetic nervous system (the origin of these tumors). LÄS MER

  7. 5. Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma

    Författare :Matilda Thorén; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small cell lung carcinoma; arsenic trioxide; hypoxia; hypoxia-inducible factors; survival; proliferation; glycolysis; glutamine metabolism; MYC;

    Sammanfattning : Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC tumors to relapse. LÄS MER