Sökning: "transmembrane topology"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden transmembrane topology.

1. 1. Transmembrane helices : tails, turns and snorkels

   Författare :Magnus Monné; Donald Engelman; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

   Sammanfattning : The assembly and structure of membrane proteins are intimately related. Targeting and insertion of membrane proteins into the endoplasmatic reticulum (ER) membrane involve many components that facilitate the folding of the native structure. LÄS MER

3. 2. Studies on the Conformation of Transmembrane Polypeptides in Membrane Proteins

   Författare :Marika Cassel; Gunnar von Heijne; Martin Spiess; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein; topology; transmembrane helix; helical hairpin; turn propensity; Biochemistry; Biokemi;

   Sammanfattning : The major aim of the studies that this thesis is based on has been to better define the topological determinants of the formation of so-called helical hairpins during membrane protein assembly in the ER membrane.The helical hairpin is a basic folding unit in membrane proteins. LÄS MER

4. 3. Transmembrane Proteins and Protein Structure Prediction : What we can learn from Computational Methods

   Författare :John Lamb; Arne Elofsson; Paolo Marcatili; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; contact prediction; transmembrane protein; topology prediction; machine learning; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : A protein’s 3D-structure is essential to understand how proteins function and interact and how biochemical processes proceed in organic life. Despite the advancement in experimental methods, it remains expensive and time-consuming to determine protein structure experimentally. LÄS MER

5. 4. Engineering membrane proteins for production and topology

   Författare :Stephen Toddo; Daniel Daley; Roslyn Bill; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Membrane protein; Over-expression; Protein production; Codon optimization; Escherichia coli; AraH; NarK; mRNA secondary structure; coding sequence; ribosome binding site; RBS; topology; split-GFP; Biochemistry; biokemi;

   Sammanfattning : The genomes of diverse organisms are predicted to contain 20 – 30% membrane protein encoding genes and more than half of all therapeutics target membrane proteins. However, only 2% of crystal structures deposited in the protein data bank represent integral membrane proteins. LÄS MER

7. 5. Topology Prediction of α-Helical Transmembrane Proteins

   Författare :Christoph Peters; Arne Elofsson; Pier Martelli; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

   Sammanfattning : Membrane proteins fulfil a number of tasks in cells, including signalling, cell-cell interaction, and the transportation of molecules. The prominence of these tasks makes membrane proteins an important target for clinical drugs. LÄS MER