Sökning: "transfection"

Visar resultat 11 - 15 av 179 avhandlingar innehållade ordet transfection.

1. 11. PepFect14, a Versatile Cell-Penetrating Peptide

   Författare :Maxime Gestin; Ülo Langel; Anna-Lena Ström; Angelita Rebollo; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-Penetrating Peptides; PepFect14; transfection; signaling mechanisms; intracellular targeting; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Cell-penetrating peptides have been discovered almost three decades ago and there are, nowadays, thousands of available sequences. They offer multiple applications in the field of drug delivery as they are able to carry therapeutic macromolecules across the plasma membrane. LÄS MER

3. 12. Characterization of nucleic acid delivery with fatty acid modified cell-penetrating peptide nanoparticle formulations

   Författare :Tõnis Lehto; Ülo Langel; Patrick Midoux; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transfection; gene delivery; oligonucleotide; complexes; non-viral; in vivo; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Recent advances with techniques used for manipulating gene expression have brought us to an era where various gene therapeutic approaches are becoming common therapeutic tools for many previously incurable diseases. The main factor impeding the wider translation of gene therapy is that the active pharmaceutical ingredients used for interfering with gene expression are based on nucleic acids and synthetic oligonucleotides and such molecules do not readily reach their intracellular targets due to their physicochemical properties and therefore they require delivery vectors to cross the cell membrane. LÄS MER

4. 13. On the Regulation of Ornithine Decarboxylase

   Författare :Eva Lövkvist Wallström; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fysiologi; Physiology; Crithidia fasciculata.; polyamines; Ornithine decarboxylase; translational control; osmolarity; untranslated region; COS cells; CHO cells; transfection; protein turnover; PEST region;

   Sammanfattning : The polyamines putrescine, spermidine and spermine have been shown to be involved in cell growth and differentiation, and are considered to be crucial components of the living cell. The synthesis of polyamines in the cell is strictly regulated. LÄS MER

5. 14. Phospholipase C β3, and its role in endocrine tumorigenesis

   Författare :Peter Stålberg; Uppsala universitet; []
   Nyckelord :Medical sciences; Phospholipase C beta 3; endocrine tumors; in situ hybridization; transfection; tumorsuppressor; differential expression; gene targeting; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : The Phospholipase C β3 (PLCB3) gene is located on chromosome 11q13, in the vicinity of theMultiple Endocrine Neoplasia type 1 (MEN1) suppressor gene. PLCB3 has been implicated inendocrine tumorigenesis based on findings of low expression in endocrine tumors, and the probableexistence of other suppressor genes located at 11q13. LÄS MER

7. 15. Transfection and transformation in Staphylococcus aureus

   Författare :Jan-Eric Sjöström; Uppsala universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

   Sammanfattning : .... LÄS MER