Sökning: "gene delivery"
Visar resultat 1 - 5 av 191 avhandlingar innehållade orden gene delivery.
1. Chitosan Polyplexes as Non-Viral Gene Delivery Systems : Structure-Property Relationships and In Vivo Efficiency
Sammanfattning : The subject of this thesis was to develop and optimize delivery systems for plasmid DNA (pDNA) based on biocompatible polymers, in particular chitosan, suitable for non-viral gene therapy. At the onset of this thesis, studies had reported conflicting results on the efficiency of chitosan-based gene delivery systems. LÄS MER
2. Chimeric gene delivery vectors : Design, synthesis, and mechanisms from transcriptomics analysis
Sammanfattning : Delivery of nucleic acid is a promising approach for genetic diseases/disorders. However, gene therapy using oligonucleotides (ONs) suffers from low transfection efficacy due to negative charges, weak cellular permeability, and enzymatic degradation. LÄS MER
3. Treatment of Skin Wounds with Cell Transplantation and Gene Transfer
Sammanfattning : Background: A large number of different wound coverings have been used in order to improve the wound microenvironment, and thus accelerate repair. Since almost two centuries, clinicians and researchers have developed techniques for skin transplantation. LÄS MER
4. Dendrimer-mediated gene delivery: Effect of polymer structure on cellular response
Sammanfattning : The delivery of nucleic acids to cells, in vitro and in vivo, is becoming a realistic approach for intervention with gene expression at a molecular level. It can be used to repair malfunctioning genes or to introduce new functionalities, with the most important application being clinical treatment of human diseases. LÄS MER
5. Nucleic acid in gene delivery and gene regulation
Sammanfattning : The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic correction led to a broadening of the concept now including the transfer of genetic material whose expression will counteract, mitigate or revert a disease phenotype. LÄS MER