Sökning: "translational control"

Visar resultat 1 - 5 av 133 avhandlingar innehållade orden translational control.

  1. 1. Modeling, control and path planning for an articulated vehicle

    Författare :Thaker Nayl; Kalevi Hyyppä; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Reglerteknik; Control Engineering;

    Sammanfattning : This licentiate thesis is focusing on the modeling, control and path planning problems for an articulated vehicle. Based on a novel error dynamics modeling approach, the nonlinear kinematic model of the vehicle has been transformed in a linear switching model representation, which is also able to take under consideration the effect of slip angles, a factor that significantly deteriorates the overall system approach. LÄS MER

  3. 2. Robustness Analysis of Intracellular Oscillators with Application to the Circadian Clock

    Författare :Camilla Trané; Elling W. Jacobsen; Eric Bullinger; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Systems Biology; Automatic control; Reglerteknik;

    Sammanfattning : Periodic oscillations underlie many intracellular functions, such as circadian time keeping, cell cycle control and locomotor pattern generation in nerve cells. These intracellular oscillations are generated in intricate biochemical reaction networks involving genes, proteins and other biochemical components. LÄS MER

  4. 3. Translational PET imaging of inflammation

    Författare :Emmi Puuvuori; Olof Eriksson; Tove Grönroos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET imaging; Nuclear Medicine; Inflammation; Translational Medicine;

    Sammanfattning : Inflammation is our body’s sophisticated defense mechanism against invading pathogens, traumas, and tumors. Repeatable and non-invasive monitoring of inflammation process would open opportunities to improve our knowledge of several diseases and enable assessment of personalized treatments. LÄS MER

  5. 4. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications

    Författare :Thi Thuy Tran; Gunnar Thorsén; McLean John; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microfluidic CD; therapeutic antibodies; post-translational modifications; glycosylation profiling; multivariate statistical analysis; MALDI-MS; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. LÄS MER

  7. 5. Post-transcriptional control of stem and cancer cell fate. New roles for an old RNA modification

    Författare :Nicola Guzzi; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA modifications; pseudouridine; translational control; Stem cells; tRNA-derived fragments; MDS;

    Sammanfattning : Recent advances in high-throughput sequencing technologies uncovered widespread RNA modifications on coding and non-coding RNAs collectively refer to as the epitranscriptome. However, we are only now starting to appreciate the impact of the epitranscriptome in regulating cell biology. LÄS MER