Sökning: "signaling mechanisms"

Visar resultat 1 - 5 av 919 avhandlingar innehållade orden signaling mechanisms.

1. 1. Melanophore signaling : regulation and application

   Författare :Tony P. M. Andersson; Ethan Lerner; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Melanophores are pigment-containing cells responsible for quick physiological color changes in lower vertebrates due to redistribution of melanosomes, pigment granules. We have studied melanophores from African clawed frog, Xenopus laevis. LÄS MER

3. 2. Mechanisms of modulation of PDGFRβ signaling

   Författare :Niki Sarri; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signalling; phosphatase; MKP2; DUSP4; deubiquitinase; USP4; USP17; E3 ligase; Cbl; TRIM21; endoribonuclease; G3BP1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Platelet-derived growth factors (PDGF) constitute a family of five functional dimers that bind to two structurally related tyrosine kinase receptors i.e. PDGF receptor α and β (PDGFRα and PDGFRβ, respectively), controlling cell growth, proliferation, and migration in cells of mesenchymal origin. LÄS MER

4. 3. Studies of PDGF receptor signaling in vitro and in vivo

   Författare :Maria Tsioumpekou; Carl-Henrik Heldin; Jean-Baptiste Demoulin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; signaling; cancer; Erk5; kinase; Cbl; ubiquitination; deubiquitinase; pericytes; tumor growth; angiogenesis; low molecular weight inhibitors;

   Sammanfattning : Platelet-derived growth factor receptor (PDGFR) signaling is essential for proliferation, migration and survival of cells of mesenchymal origin; however, its deregulation has been associated with various diseases, including cancer. The aim of this thesis was to clarify the molecular mechanisms of PDGFR signaling regulation. LÄS MER

5. 4. Regulatory mechanisms of amino acid-induced signaling in Saccharomyces cerevisiae

   Författare :Deike J. Omnus; Per O. Ljungdahl; Claudio De Virgilio; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Signal transduction; regulatory mechanisms; nutrient sensing; Saccharomyces cerevisiae; Cell Biology; cellbiologi;

   Sammanfattning : This thesis describes studies aimed at elucidating the molecular mechanisms that regulate the SPS (Ssy1-Ptr3-Ssy5) signal transduction pathway in the yeast Saccharomyces cerevisiae. This pathway is induced by extracellular amino acids and facilitates their uptake. LÄS MER

7. 5. Chemoattractant receptor signaling and neutrophil acctivation. Involvement of the cytoskeleton

   Författare :Huamei Fu; Göteborgs universitet; []
   Nyckelord :neutrophils; G-protein coupled receptors; signaling; cytoskeleton;

   Sammanfattning : Neutrophil granulocytes play a vital role in the host surveillance system and form the first line of defense against microbial infections. The migration of neutrophils to an infected/inflamed tissue is guided by chemoattractants released either from intruding microbes or from activated/damaged host cells. LÄS MER