Sökning: "trans splicing"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden trans splicing.

  1. 1. The balance of splicing : A novel insight into the splicing regulation of high-risk HPV E6 and E7 oncogenes

    Författare :Johanna Jönsson; Naoko Kajitani; Stefan Schwartz; Ola Forslund; Francesca Aguilo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HPV; splice donor; splice acceptor; cis-element; trans-acting factor; pre-mRNA splicing; splicing regulation.; Medical Virology; Medicinsk virologi;

    Sammanfattning : HPV is associated with several cancers. The genome consists of a long control region, early (E1, E2, E4, E5, E6 and E7) and late (L1 and L2) genes. The E6 and E7 proteins prevent cells from entering apoptosis and regulate the cell cycle. A deregulated expression of these can result in malignant transformations. LÄS MER

  3. 2. The SWI/SNF complex : Roles in transcription and pre-mRNA processing

    Författare :Johan Waldholm; Neus Visa; Ann-Kristin Östlund; Silvia Barabino; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Splicing; Gene regulation; SWI SNF; polyadenylation; Molecular Biology; molekylärbiologi;

    Sammanfattning : The regulation of gene expression is fundamental to the development of complex organisms and an important driving force in this process. When and where the genes are expressed decide the fate of a cell and its physiological context in the organism. LÄS MER

  4. 3. ATPase dependent and independent roles of Brahma in transcription and pre-mRNA processing

    Författare :Simei Yu; Neus Visa; Ann-Kristin Östlund Farrants; Christian Muchardt; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chromatin remodeling; transcription; alternative splicing; 3 -end processing; Molecular Biology; molekylärbiologi;

    Sammanfattning : SWI/SNF is a chromatin-remodeling complex and Brahma (BRM) is the ATPase subunit of SWI/SNF. BRM regulates transcription by remodeling the nucleosomes at promoter regions. BRM is also associated with RNA and affects pre-mRNA processing together with other SWI/SNF subunits. LÄS MER

  5. 4. Functional Significance of Multiple Poly(A) Polymerases (PAPs)

    Författare :Helena Nordvarg; Claire Moore; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; poly A polymerase; PAP; phosphorylation; isoforms; alternative splicing; kinetic parameters; hyperphosphorylation; regulation; Genetik; Poly A polymeras; PAP; fosforylering; isoformer; alternativ splitsning; kinetiska parametrar; reglering; Clinical genetics; Klinisk genetik; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : 3’ end cleavage and polyadenylation are important steps in the maturation of eukaryotic mRNAs. Poly(A) polymerase (PAP), the enzyme catalysing the addition of adenosine residues, exists in multiple isoforms. In this study the functional significance of multiple poly(A) polymerases have been investigated. LÄS MER

  7. 5. Genomic feature identification in trypanosomatid parasites

    Författare :Daniel Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Trypanosoma cruzi; genome sequence; bioinformatics; gene finding; Trypanosoma brucei; Leishmania major; strand asymmetry; trans splicing; polyadenylation; post-transcriptional control; uAUGs.;

    Sammanfattning : The trypanosomatid parasites cause death and suffering, among humans as well as livestock. Current drugs lack efficacy and cause severe side effects, and no vaccines are available. Increased knowledge of the biology of the parasites is vital for the development of new drugs. LÄS MER