Sökning: "isoformer"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet isoformer.

  1. 1. Functional Significance of Multiple Poly(A) Polymerases (PAPs)

    Författare :Helena Nordvarg; Claire Moore; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; poly A polymerase; PAP; phosphorylation; isoforms; alternative splicing; kinetic parameters; hyperphosphorylation; regulation; Genetik; Poly A polymeras; PAP; fosforylering; isoformer; alternativ splitsning; kinetiska parametrar; reglering; Clinical genetics; Klinisk genetik; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : 3’ end cleavage and polyadenylation are important steps in the maturation of eukaryotic mRNAs. Poly(A) polymerase (PAP), the enzyme catalysing the addition of adenosine residues, exists in multiple isoforms. In this study the functional significance of multiple poly(A) polymerases have been investigated. LÄS MER

  3. 2. Protein kinase C epsilon and neurite outgrowth

    Författare :Ruth Zeidman; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ;

    Sammanfattning : Protein kinase C (PKC) is a serine/threonine kinase family with 10 identified isoforms. The contribution of PKC isoforms to cell growth and differentiation, with focus on neurite outgrowth, was investigated, using neuroblastoma and immortalised neural cells as model systems. LÄS MER

  4. 3. The art of transcriptome reconstruction : with applications in Picea abies (L.) H. Karst

    Författare :Karl Johan Westrin; Olof Emanuelsson; Henric Zazzi; Lukas Käll; Jens Sundström; Jarkko Salojärvi; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; transcriptome reconstruction; transcriptome assembly; transcript isoform detection; Picea abies; acrocona; cone setting; differential expression; gene families; miRNA; quality assessment; transkriptomrekonstruktion; sammansättning av transkriptom; detektering av transkriptisoform; rödgran; kottegran; kottsättning; differentiellt uttryck; genfamiljer; kvalitetsutvärdering; miRNA; Biotechnology; Bioteknologi;

    Sammanfattning : Transcriptome reconstruction is an important component in the bioinformatical part of transcriptome studies. When a reference genome is missing, highly fragmented or incomplete, a de novo transcriptome assembly is the transcriptome reconstruction approach of choice, since in such situations, a simple alignment (or mapping) would not necessarily give all theinformation concerning splice junctions, isoforms or even the full extent of the gene. LÄS MER

  5. 4. Methods for transcriptome reconstruction, with an application in Picea abies (L.) H. Karst

    Författare :Karl Johan Westrin; Olof Emanuelsson; Björn Nystedt; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acrocona; cone setting; transcript isoform detection; miRNA; Picea abies; quality assessment; transcriptome assembly; Bioteknologi; Biotechnology;

    Sammanfattning : Transcriptome reconstruction is an important component in the bioinformatical part of transcriptome studies. It is particulary interesting when a reference genome is missing, highly fragmented or incomplete, since in such situations, a simple alignment (or mapping) would not necessarily tell the full story. LÄS MER

  7. 5. The role of PKC in neuronal differentiation and in regulation of the actin cytoskeleton during neurite outgrowth

    Författare :Ulrika Trollér; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetics; Genetik; cytogenetik; Rho-family; actin cytoskeleton; neurite; differentiation; PKC; regulatory domain; Genetics;

    Sammanfattning : Protein kinase C (PKC) is a family of serine/threonine kinases subgrouped into classical (α, βI, βII, γ), novel (δ, ε, η, θ) and atypical (ζ, ι/λ) isoforms. PKC can be activated by phorbol esters, and prolonged treatment of neuroblastoma cells has been shown to induce neuronal differentiation with neurite outgrowth and increased expression of neuronal genes. LÄS MER