Sökning: "poly A polymerase"
Visar resultat 1 - 5 av 34 avhandlingar innehållade orden poly A polymerase.
1. Regulation of Mammalian Poly(A) Polymerase Activity
Sammanfattning : Poly(A) polymerase (PAP) is the enzyme catalyzing the synthesis of the adenine tail to the 3’-end of mRNA. This A-tail is present on the majority of the primary RNA transcripts of protein-coding genes, and is important for mRNA stability, export to the cytoplasm and translation. Therefore, PAP is a key regulator of eukaryotic gene expression. LÄS MER
2. Functional Significance of Multiple Poly(A) Polymerases (PAPs)
Sammanfattning : 3’ end cleavage and polyadenylation are important steps in the maturation of eukaryotic mRNAs. Poly(A) polymerase (PAP), the enzyme catalysing the addition of adenosine residues, exists in multiple isoforms. In this study the functional significance of multiple poly(A) polymerases have been investigated. LÄS MER
3. Characterization of toxicological effects of a novel in vivo benzo[a]pyrene metabolite in colonic cells
Sammanfattning : Cancer of the colon and rectum is the third most common cancer form in the world. Where the majority of cases fall into the category of sporadic colorectal cancer (CRC), lifestyle and diet have been found to be important risk factors associated with CRC. LÄS MER
4. Apoptosis And Excitotoxicity In The Death of Cultured And Grafted Dopaminergic Neurones
Sammanfattning : Over the past two decades, grafting of embryonic nigral tissue has developed into a feasible therapeutic strategy for Parkinson's disease (PD). It has become apparent that the degree of restoration of dopaminergic neurotransmission by the transplanted cells is highly correlated to the symptomatic relief. LÄS MER
5. Engineering Surfaces of Solid-State Nanopores for Biomolecule Sensing
Sammanfattning : Nanopores have emerged as a special class of single-molecule analytical tool that offers immense potential for sensing and characterizing biomolecules such as nucleic acids and proteins. As an alternative to biological nanopores, solid-state nanopores present remarkable versatility due to their wide-range tunability in pore geometry and dimension as well as their excellent mechanical robustness and stability. LÄS MER