Sökning: "tandem repeat"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden tandem repeat.

  1. 1. Evolutionary genomics in Corvids : – From single nucleotides to structural variants

    Författare :Matthias H. Weissensteiner; Jochen B.W. Wolf; Manfred Grabherr; Kateryna M. Makova; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; evolutionary genetics; genomics; population genetics; selection; recombination; chromosomal features; colouration; insertion; deletion; inversion; crow; tandem repeat; transposable element; gene expression;

    Sammanfattning : Heritable genetic variation is the raw material of evolution and can occur in many different forms, from altering single nucleotides to rearranging stretches of millions at once. DNA mutations that result in phenotypic differences are the basis upon which natural selection can act, leading to a shift of the frequency of those mutations. LÄS MER

  3. 2. Parallel target selection by trinucleotide threading

    Författare :Pawel Zajac; Joakim Lundeberg; Afshin Ahmadian; Mats Nilsson; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; trinucleotide threading; multiplex amplification; expression profiling; microarray; generic tag; short tandem repeat; microsatellite; electrophoresis; single nucleotide polymorphism; allelotyping; 454; Pyrosequencing; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Sammanfattning : DNA is the code for all life. Via intermediary RNA the information encoded by the genome is relayed to proteins executing the various functions in a cell. Together, this repertoire of inherently linked biological macromolecules determines all characteristics and features of a cell. LÄS MER

  4. 3. Creation of new proteins - domain rearrangements and tandem duplications

    Författare :Åsa Björklund; Arne Elofsson; Sarah Teichmann; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

    Sammanfattning : Proteins are modular entities with domains as their building blocks. The domains are recurrent protein fragments with a distinct structure, function and evolutionary history. During evolution, proteins with new functions have been invented through rearrangements as well as differentiation of domains. LÄS MER

  5. 4. Assessing the structural and dynamical properties of concentrated solutions of the disordered proteins Histatin 5 and its tandem repeat

    Författare :Eric Fagerberg; Beräkningskemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Simulation; IDP; crowding;

    Sammanfattning : Intrinsically disordered proteins are distinguished by a lack of distinct three-dimensional structure, existing instead as an ensemble of heterogenous structures. In this research, the effect of crowding on these proteins is investigated using a combined approach of experiment and computer simulation, mainly using coarse-grained simulation models to make simulation computationally feasible at the high concentration conditions crowding is displayed. LÄS MER

  7. 5. Variation in length of proteins by repeats and disorder regions

    Författare :Rauan Sagit; Arne Elofsson; Andrey Kajava; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein length; repeats; domain repeats; protein evolution; duplication; tandem duplication; intrinsic disorder; intrinsically disordered; variation in length; insertion; deletion; recombination; expansion; contraction; Biochemistry; biokemi;

    Sammanfattning : Protein-coding genes evolve together with their genome and acquire changes, some of which affect the length of their protein products. This explains why equivalent proteins from different species can exhibit length differences. LÄS MER