Sökning: "Manfred Grabherr"

Hittade 4 avhandlingar innehållade orden Manfred Grabherr.

  1. 1. Integrating multi-omics for type 2 diabetes : Data science and big data towards personalized medicine

    Författare :Klev Diamanti; Jan Komorowski; Claes Wadelius; Manfred Grabherr; Peter Spégel; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; multi-omics; genomics; metabolomics; data science; machine learning; personalized medicine; Bioinformatics; Bioinformatik;

    Sammanfattning : Type 2 diabetes (T2D) is a complex metabolic disease characterized by multi-tissue insulin resistance and failure of the pancreatic β-cells to secrete sufficient amounts of insulin. Cells recruit transcription factors (TF) to specific genomic loci to regulate gene expression that consequently affects the protein and metabolite abundancies. LÄS MER

  3. 2. The revolutionary partnership of computation and biology

    Författare :Salvador Daniel Rivas-Carrillo; Tanel Punga; Manfred Grabherr; Jan Komorowski; Mauno Vihinen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The organization of living beings is complex. Science uses modeling in order to gain a deeper understanding, and to be able to manipulate the processes of living organisms. To this purpose, I used and developed computational tools to investigate and model different relevant biological phenomena. LÄS MER

  4. 3. Computational discovery of DNA methylation patterns as biomarkers of ageing, cancer, and mental disorders : Algorithms and Tools

    Författare :Behrooz Torabi Moghadam; Jan Komorowski; Manfred Grabherr; Jaak Vilo; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA methylation; machine learning; biomarker; cancer; ageing; classification;

    Sammanfattning : Epigenetics refers to the mitotically heritable modifications in gene expression without a change in the genetic code. A combination of molecular, chemical and environmental factors constituting the epigenome is involved, together with the genome, in setting up the unique functionality of each cell type. LÄS MER

  5. 4. Evolutionary genomics in Corvids : – From single nucleotides to structural variants

    Författare :Matthias H. Weissensteiner; Jochen B.W. Wolf; Manfred Grabherr; Kateryna M. Makova; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; evolutionary genetics; genomics; population genetics; selection; recombination; chromosomal features; colouration; insertion; deletion; inversion; crow; tandem repeat; transposable element; gene expression;

    Sammanfattning : Heritable genetic variation is the raw material of evolution and can occur in many different forms, from altering single nucleotides to rearranging stretches of millions at once. DNA mutations that result in phenotypic differences are the basis upon which natural selection can act, leading to a shift of the frequency of those mutations. LÄS MER