Sökning: "synapse"

Visar resultat 6 - 10 av 90 avhandlingar innehållade ordet synapse.

1. 6. Regulation of RNA Editing : The impact of inosine on the neuronal transcriptome

   Författare :Mikaela Behm; Marie Öhman; André Gerber; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editing; ADAR; miRNA; Neuron; Brain development; Synapse; Molecular Biology; molekylärbiologi;

   Sammanfattning : The transcriptome of the mammalian brain is extensively modified by adenosine to inosine (A-to-I) nucleotide conversion by two adenosine deaminases (ADAR1 and ADAR2). As adenosine and inosine have different base pairing properties, A-to-I RNA editing shapes the functional output of both coding and non-coding RNAs (ncRNAs) in the brain. LÄS MER

3. 7. Molecular mechanisms of synaptic transmission and plasticity in spinal sensory pathways

   Författare :Max Larsson; Neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; neuropsychology; Neurology; electron microscopy; synaptic plasticity; synapse; pain; spinal cord; hyperalgesia; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : An intense, potentially tissue-damaging (noxious) stimulus may lead to enhanced pain sensation of subsequent noxious stimuli (hyperalgesia) and to the perceiving of innocuous stimuli as painful (allodynia). This is thought to result to a large extent from strengthening of synapses established by primary afferent fibers onto spinal cord dorsal horn neurons. LÄS MER

4. 8. Short- and long-term neuronal plasticity in hippocampal CA1 region of rat

   Författare :Fen-Sheng Huang; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glutamate; hippocampus; plasticity; synapse; LTP; LTD; AMPA; NMDA;

   Sammanfattning : The brain is highly plastic, displaying both short- and long-term changes, resulting from developmental processes as well as learning and memory. Moreover, short-term plasticity such as paired pulse facilitation and depression (PPF, PPD) have long been used to monitor the presynaptic versus postsynaptic changes occurring during more lasting processes such as long-term potentiation and depression (LTP, LTD). LÄS MER

5. 9. Plasticity and variation of synaptic responses in hippocampus. Role of AMPA and NMDA receptors

   Författare :Yin-Ping Niu; Göteborgs universitet; []
   Nyckelord :learning and memory; synaptic plasticity; hippocampus; synapse; AMPA receptor; NMDA receptor; LTP; LTD; CV; TFS;

   Sammanfattning : It is generally believed that synaptic plasticity in the central nervous system may underlie learning and memory as well as neuronal development. The most wellstudied examples of such synaptic plasticity are long-term potentiation (LTP) andlong-term depression (LTD). LÄS MER

7. 10. Differences in glutamatergic transmission onto interneurons and pyramidal cells in the rat hippocampus

   Författare :Ilse Riebe; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AMPA; development; glutamate transmission; hippocampus; interneuron; NMDA; synapse;

   Sammanfattning : In the human brain there are about 100 billion excitatory glutamatergic neurons and 10 billion inhibitory GABAergic neurons. During development, these neurons are synaptically wired together into neural networks, functionally prepared to perform the full register of brain functions, and to learn from experiences. LÄS MER