Sökning: "substitutions"
Visar resultat 16 - 20 av 202 avhandlingar innehållade ordet substitutions.
16. Evolutionary Approaches to Sequence Alignment
Sammanfattning : Molecular evolutionary biology allows us to look into the past by analyzing sequences of amino acids or nucleotides. These analyses can be very complex, often involving advanced statistical models of sequence evolution to construct phylogenetic trees, study the patterns of natural selection and perform a number of other evolutionary studies. LÄS MER
17. Generic Drug Switch in Epilepsy – Pharmacokinetic and Clinical Aspects
Sammanfattning : Background and aim: Generic drugs contain the same active ingredients as brand- name drugs, with the advantage of much lower costs. The aim of this thesis was to contribute new knowledge to the ongoing debate on the safety of generic antiseizure drug (ASD) substitutions. There was a particular emphasis on the pharmacokinetic and clinical outcomes. LÄS MER
18. Prescription – Pollution – Poo – Pandemics - Priorities : Neuraminidase Inhibitors from an Environmental Resistance Development Perspective
Sammanfattning : The natural Influenza A virus (IAV) host is waterfowl. Human IAV is treated with neuraminidase inhibitors (NAIs), which are stockpiled worldwide in case of an IAV pandemic. As the drugs escape regular waste water treatment, they can be detected in river waters. LÄS MER
19. On the molecular mechanisms of the amyloid β-peptide aggregation
Sammanfattning : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. LÄS MER
20. Synthesis of new building blocks for conjugated oligomers
Sammanfattning : This thesis deals with the synthesis of new organicmaterials for electronic applications. Several new ring-formingmethods are employed to construct sulphur heterocycles: Tandemelectrophilic aromatic substitution and acid-catalyzedtransetherification of methoxythiophene, double electrophilicaromatic substitutions with ethane-1, 2-disulphenyl chloride,and also, the reaction of dienes with sulphur dichloride. LÄS MER