Sökning: "Josef D. Järhult"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Josef D. Järhult.

  1. 1. Tamiflu® - Use It and Lose It?

    Författare :Josef D. Järhult; Björn Olsen; Hanna Söderström; Jonas Waldenström; Robert G. Webster; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; oseltamivir; Tamiflu; resistance development; H274Y; environment; pharmaceuticals; mallard; dabbling duck; avian influenza; influensa; resistensutveckling; miljö; läkemedel; gräsand; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Influenza A viruses cause seasonal and pandemic outbreaks that range from mild infections to the disastrous Spanish Flu. Resistance to neuraminidase inhibitors (NAIs) is a growing problem as these drugs constitute a vital part of treatment strategies and pandemic preparedness plans worldwide. Oseltamivir (Tamiflu®) is the mostly used NAI. LÄS MER

  3. 2. Identification of protease inhibitors against Flaviviruses and Coronaviruses

    Författare :Dario Akaberi; Åke Lundkvist; Johan Lennerstrand; Josef D. Järhult; Ujjwal Neogi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antiviral research; protease inhibitors; flaviviruses; coronaviruses; ZIKV; TBEV; SARS-CoV-2;

    Sammanfattning : Vector-borne flaviviruses and coronaviruses of zoonotic origins are important human pathogens and represent a serious threat to public health worldwide. Flaviviruses can be found on all continents, apart from Antarctica, where they are transmitted by arthropod vectors causing millions of infections every year. LÄS MER

  4. 3. Antibiotic resistance gone wild : A One Health perspective on carriage, selection and transmission of Extended-Spectrum Cephalosporinase- and Carbapenemase-producing Enterobacteriaceae

    Författare :Clara Atterby; Josef D. Järhult; Nicola Williams; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; E. coli; K. pneumoniae; ESBL; AmpC; Carbapenemase; ciprofloxacin resistance; colistin resistance; rural; wildlife; birds; sub-MIC; MSC; Cambodia; environment; epidemiology; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Antibiotics have saved millions of lives since they came into clinical use during the Second World War in the 1940s. Today, our effective use of antibiotics is under great threat due to emerging antibiotic resistance in bacteria. This thesis addresses the problems of antibiotic resistance from a ”One Health” perspective. LÄS MER

  5. 4. Avian Influenza Virus : Deciphering receptor interactions and their role in interspecies transmission

    Författare :Per Eriksson; Patrik Ellström; Björn Olsen; Josef D. Järhult; Åke Lundkvist; Jonas Waldenström; Hans-Dieter Klenk; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; birds; glycobiology; glycovirology; host range; mixing vessel; virus attachment; Medical Virology; Medicinsk virologi;

    Sammanfattning : Influenza A virus (IAV) annually infects approximately 5–15 % of the human population, causing ~500,000 deaths globally. Novel IAVs have emerged and spread pandemically in the human population, but have over time established endemic circulation with reduced pathogenicity causing seasonal influenza. The natural reservoir of IAVs is wild waterfowl. LÄS MER

  7. 5. Tamiflu in the Water : Resistance Dynamics of Influenza A Virus in Mallards Exposed to Oseltamivir

    Författare :Anna Gillman; Josef D Järhult; Björn Olsen; Shaman Muradrasoli; Elena Govorkova; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Influenza A virus; avian influenza; oseltamivir; neuraminidase inhibitors; resistance; environmental; Mallard; waterfowl; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The natural reservoir of influenza A virus (IAV) is wild waterfowl, and all human IAVs have their genetic origins from avian viruses. Neuraminidase inhibitors (NAIs) are currently the best drugs for treatment of human influenza; therefore, the orally available NAI oseltamivir (Tamiflu®) has been stockpiled worldwide as part of pandemic preparedness planning. LÄS MER