Sökning: "cross-seeding"

Hittade 4 avhandlingar innehållade ordet cross-seeding.

  1. 1. On the molecular mechanisms of the amyloid β-peptide aggregation

    Författare :Kalyani Sanagavarapu; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein aggregation; amyloid β-peptide; aggregation kinetics; aggregation mechanism N-terminus; mutations; variants; sequence determinants; ; cross-seeding;

    Sammanfattning : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. LÄS MER

  3. 2. Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease

    Författare :Marie Oskarsson; Gunilla Westermark; Mikael Oliveberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; Abeta; type 2 diabetes; Alzheimer disease; BRICHOS; heparan sulfate; islet amyloid; amyloid plaques; seeding; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main pathological finding in islets of Langerhans in type 2 diabetes. Pathological assemblies of IAPP are cytotoxic and believed to contribute to the loss of insulin-producing beta cells. LÄS MER

  4. 3. Fluorescent Probes and Protein Misfolding: Methods and Applications

    Författare :Irem Nasir; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; fluorophores; filter-trap; site-specific fluorophore labeling; amyloid-beta; microscopic rate constants; solvatochromic probes; alpha-synuclein; lipid vesicles; nanoparticles; protein adsorption;

    Sammanfattning : Protein misfolding is a frequently occurring event in living cells and without the quality control, the consequences are disasterous. In this thesis, we studied protein misfolding in vitro by employing a variety of fluorophores, to either detect the highly ordered aggregates of intrinsically disordered proteins/peptides or slight misfolding of a natively folded protein. LÄS MER

  5. 4. Islet Amyloid Polypeptide: Interaction with Amyloid Beta, Alpha-Synuclein and BRICHOS

    Författare :Ye Wang; Gunilla Westermark; Ludmilla Morozova-Roche; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; Abeta; alpha-synuclein; Bri2 BRICHOS; luminescent conjugated oligothiophenes; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning :  Amyloid, the congophilic deposits of misfolded protein, are pathological hallmarks of many common diseases, among others, Alzheimer’s disease (AD), Parkinson’s disease (PD), and type 2 diabetes (T2D). Amyloid beta (Aβ) forms senile plaques in AD, alpha-synuclein (aSyn) forms Lewy bodies and Lewy neurites in PD, islet amyloid polypeptide (IAPP) forms islet amyloid in T2D. LÄS MER