Sökning: "splicing silencer"
Hittade 4 avhandlingar innehållade orden splicing silencer.
1. Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing
Sammanfattning : Human papillomaviruses (HPVs) cause almost half of the human cancers that are attributable to viruses. HPV type 16 is the most carcinogenic type among the HPVs and is detected in 50% of all cervical cancers. HPV-16 infects epithelial cells and HPV-16 gene expression is tightly linked to the differentiation stage of the infected cells. LÄS MER
2. The balance of splicing : A novel insight into the splicing regulation of high-risk HPV E6 and E7 oncogenes
Sammanfattning : HPV is associated with several cancers. The genome consists of a long control region, early (E1, E2, E4, E5, E6 and E7) and late (L1 and L2) genes. The E6 and E7 proteins prevent cells from entering apoptosis and regulate the cell cycle. A deregulated expression of these can result in malignant transformations. LÄS MER
3. Regulation of Human Papillomavirus Type 16 mRNA Splicing and Polyadenylation
Sammanfattning : Human papillomavirus type 16 (HPV-16) is the major causative agent of cervical cancer. The life cycle of this oncogenic DNA tumour virus is strictly associated with the differentiation program of the infected epithelial cells. Expression of the viral capsid genes L1 and L2 can only be detected in the terminally differentiated epithelial cells. LÄS MER
4. Functional analysis of genetic variants in putative low penetrate breast cancer genes
Sammanfattning : Paper I & II: CDH1 germline mutations predispose individuals to diffuse gastric cancer, but its role in breast cancer is less clear. Somatic CDH1 mutations were reported to be frequent in lobular tumours (ILC), but they have not been found in ductal carcinomas (IDC). LÄS MER