Sökning: "Haixin Lei"

Hittade 1 avhandling innehållade orden Haixin Lei.

1. 1. Functional analysis of genetic variants in putative low penetrate breast cancer genes

   Författare :Haixin Lei; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Breast cancer; low penetrance gene; CDH1; ILC; IDC; mutation; SNP; BA CHI; ATM; EST1; cryptic splice site; SR proteins; dinucleotide repeats; splicing silencer.;

   Sammanfattning : Paper I & II: CDH1 germline mutations predispose individuals to diffuse gastric cancer, but its role in breast cancer is less clear. Somatic CDH1 mutations were reported to be frequent in lobular tumours (ILC), but they have not been found in ductal carcinomas (IDC). LÄS MER