Sökning: "Barklie Clements"

Hittade 2 avhandlingar innehållade orden Barklie Clements.

1. 1. Regulation of Mammalian Poly(A) Polymerase Activity

   Författare :Ann-Charlotte Thuresson; Barklie Clements; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; poly A polymerase; PAP; polyadenylation; isoforms; phosphorylation; alternative splicing; CPSF interaction; aminoglycosides; Biomedicin; Microbiology; Mikrobiologi; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Poly(A) polymerase (PAP) is the enzyme catalyzing the synthesis of the adenine tail to the 3’-end of mRNA. This A-tail is present on the majority of the primary RNA transcripts of protein-coding genes, and is important for mRNA stability, export to the cytoplasm and translation. Therefore, PAP is a key regulator of eukaryotic gene expression. LÄS MER

3. 2. Regulation of Human Papillomavirus Type 16 mRNA Splicing and Polyadenylation

   Författare :Xiaomin Zhao; Stefan Schwartz; Barklie Clements; Uppsala universitet; []
   Nyckelord :Medical sciences; human papillomavirus type 16; gene regulation; splicing; polyadenylation; 3 UTR; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

   Sammanfattning : Human papillomavirus type 16 (HPV-16) is the major causative agent of cervical cancer. The life cycle of this oncogenic DNA tumour virus is strictly associated with the differentiation program of the infected epithelial cells. Expression of the viral capsid genes L1 and L2 can only be detected in the terminally differentiated epithelial cells. LÄS MER