Sökning: "specific IgE"

Visar resultat 6 - 10 av 133 avhandlingar innehållade orden specific IgE.

  1. 6. Feedback Enhancement of Immune Responses by IgE, IgM, and IgG3 Antibodies

    Författare :Zhoujie Ding; Birgitta Heyman; Eva Severinson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgE; IgM; IgG3; antibody responses; T-cell responses; antigen transportation; antigen presentation; complement; complement receptors 1 and 2; Immunologi; Immunology;

    Sammanfattning : Antibodies can enhance or suppress the immune responses against their specific antigens. This phenomenon is known as antibody-mediated feedback regulation. We have studied the mechanisms underlying IgE-, IgM-, and IgG3-mediated enhancement of immune responses in mouse models using intravenous immunization. LÄS MER

  3. 7. Use of Recombinant Allergens for Component-Resolved Diagnostics (CRD) in IgE-Mediated Allergy

    Författare :Åsa Marknell DeWitt; Pia Ek; Jonas Lidholm; Ronald van Ree; Uppsala universitet; []
    Nyckelord :Biomedical laboratory science; recombinant allergen; IgE; component-resolved diagnostics; CRD; tropomyosin; Phl p 11; Phl p 4; Pen a 1; Hev b 5; Biomedicinsk laboratorievetenskap;

    Sammanfattning : Immunoglobulin E (IgE)-mediated allergy occurs when our immune system causes a reaction to otherwise harmless substances (allergens). Allergens are predominantly proteins present in biological materials such as pollens, mites, animal epithelia, moulds and foods. LÄS MER

  4. 8. Human IgE - What We Can Learn from Repertoire Studies and How We Can Use Them as Tools

    Författare :Mattias Levin; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allergy; antibodies; IgE; transcriptome analysis; immunotherapy; molecular biology;

    Sammanfattning : Antibodies of the IgE isotype play a key role as the allergen recognizer in allergic disease, which today affects as much as a third of the population in the industrialized parts of the world. Despite this crucial role of IgE, our knowledge of IgE repertoires and how we can utilize the information hidden in monoclonal IgE to improve the quality of life of allergic patients, is limited. LÄS MER

  5. 9. Early life cytokines, viral infections and IgE-mediated allergic disease

    Författare :Anna-Karin Larsson; Marita Troye-Blomberg; Gunnar Lilja; Maria Jenmalm; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; IgE-sensitisation; childhood; cytokine; viral infection; atopy; single nucleotide polymorphism; cord blood; Immunology; Immunologi;

    Sammanfattning : Background: The reasons why some individuals become IgE-sensitised and allergic are largely unknown, though genetic- and early life environmental factors seem to be of importance.Objective: The overall aim of this thesis was to investigate the relationship between IgE-sensitisation and allergic disease, viral infections, genetic markers and early life cytokines. LÄS MER

  7. 10. Feedback Enhancement of Antibody Responses via Complement and Fc Receptors

    Författare :Jörgen Dahlström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mouse; transgenic knockout; immune regulation; B lymphocytes; Fc receptors; complement; IgG; IgM; IgE; Fc-gamma-RI; Fc-gamma-RII; Fc-gamma-RIII; CR1; CR2; CD21; CD35; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : IgG, IgM and IgE in complex with antigen have the capacity to regulate specific immune responses. In this investigation, the role of Fc receptors for IgG (FcγRI, FcγRII and FcγRIII) and complement receptors 1 and 2 (CR1/2) for antibody-mediated enhancement of antibody responses are investigated. LÄS MER