Sökning: "transgenic knockout"

Visar resultat 1 - 5 av 59 avhandlingar innehållade orden transgenic knockout.

  1. 1. Effects of growth hormone on bone tissue in transgenic mice

    Författare :Jonas Sandstedt; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; bone; ovariectomy; orchidectomy; growth; Interleukin-6; titanium; transgenic mice;

    Sammanfattning : Growth hormone (GH) affect bone-tissue in both humans and rodents. Also sex steroids are important for growth and the maintenance of normal bone physiology. The specific aims of this study were to investigate how high levels of GH affects bone tissue in mice and to determine whether these effects are dependent on an intact gonadal function. LÄS MER

  3. 2. Feedback Enhancement of Antibody Responses via Complement and Fc Receptors

    Författare :Jörgen Dahlström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mouse; transgenic knockout; immune regulation; B lymphocytes; Fc receptors; complement; IgG; IgM; IgE; Fc-gamma-RI; Fc-gamma-RII; Fc-gamma-RIII; CR1; CR2; CD21; CD35; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : IgG, IgM and IgE in complex with antigen have the capacity to regulate specific immune responses. In this investigation, the role of Fc receptors for IgG (FcγRI, FcγRII and FcγRIII) and complement receptors 1 and 2 (CR1/2) for antibody-mediated enhancement of antibody responses are investigated. LÄS MER

  4. 3. Fcγ Receptors in the Immune Response

    Författare :Teresita Díaz de Ståhl; Jan van de Winkel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Fc Receptors; IgG Receptors; IgE Receptors; Immune regulation; In vivo animal models; Mouse; Rh prophylaxis; Rheumatoid arthritis; Transgenic knockout; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Circulating immune complexes play an important role in the modulation of antibody responses and in the pathogenesis of immune diseases. This thesis deals with the in vivo regulatory properties of antibodies and their specific Fc receptors. LÄS MER

  5. 4. The role of the complement system in arthritis and stroke

    Författare :Max Albert Hietala; Göteborgs universitet; []
    Nyckelord :complement; C3; factor B; transgenic knockout; arthritis; focal cerebral ischemia;

    Sammanfattning : Complement is part of the innate immune system and functions primarily as a first line of defense against invading microorganisms. It is a complex cascade, which can be activated via three pathways: the classical, alternative and mannan-binding lectin pathway. LÄS MER

  7. 5. Fc receptors and feedback enhancement of antibody responses

    Författare :Sara Wernersson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mouse; transgenic knockout; immune regulation; B lymphocytes; Fc receptors; IgG; IgE; FcgRI; FcgRII; FcgRIII; CD23; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Antibodies are important for the defence against microorganisms, but are also involved inpathological reactions such as allergy or autoimmunity. The exact mechanisms involved inregulation of antibody responses is still largely unknown. In this thesis, immune regulationby antibodies and the receptors they bind to (FcR), were investigated. LÄS MER