Sökning: "CD35"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet CD35.

  1. 1. Feedback Enhancement of Antibody Responses via Complement and Fc Receptors

    Författare :Jörgen Dahlström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mouse; transgenic knockout; immune regulation; B lymphocytes; Fc receptors; complement; IgG; IgM; IgE; Fc-gamma-RI; Fc-gamma-RII; Fc-gamma-RIII; CR1; CR2; CD21; CD35; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : IgG, IgM and IgE in complex with antigen have the capacity to regulate specific immune responses. In this investigation, the role of Fc receptors for IgG (FcγRI, FcγRII and FcγRIII) and complement receptors 1 and 2 (CR1/2) for antibody-mediated enhancement of antibody responses are investigated. LÄS MER

  3. 2. Skin hydration - How water and osmolytes influence biophysical properties of stratum corneum

    Författare :Sebastian Björklund; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stratum corneum; diffusive transport; permeability; flow-through cell; Franz cell; transdermal drug delivery; water activity; vapor pressure; osmotic gradient; relative humidity; ceramide; free fatty acid; cholesterol; keratin filaments; natural moisturizing factor NMF ; urea; glycerol; molecular mobility; 13C natural-abundance solid-state NMR; polarization transfer; isothermal calorimetry; impedance spectroscopy; X-ray diffraction;

    Sammanfattning : The outermost layer of skin (i.e., the stratum corneum, SC) is the interface that separates the water-rich inside of the body from the relatively dry external environment. SC forms an effective permeability barrier, which has to be overcome in transdermal drug delivery. LÄS MER

  4. 3. Computational Single-Cell Genomics Methods for Cell State Estimation and their Application to Hematopoietic Systems

    Författare :Parashar Dhapola; Avdelningen för molekylär hematologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic Stem Cell; Single-Cell; Genomics; Epigenomics; transcriptomics; bioinformatics;

    Sammanfattning : The focus of this doctoral dissertation was to develop novel and scalable computational genomics methods for analysing single-cell genomic modalities. Scarf, a highly memory-efficient single-cell data analysis toolkit, was developed to enable an analysis of very large-scale datasets on personal computers, and the execution of parallel workflows on server-scale computational systems. LÄS MER

  5. 4. Neutrophil Chemotaxis and Respiratory Burst in Term and Preterm Newborn Infants

    Författare :Maria Stålhammar; Richard Sindelar; Jens Schollin; Uppsala universitet; []
    Nyckelord :innate immunity; neutrophil; term newborn infants; preterm newborn infants; chemotaxis; respiratory burst; reactive oxygen species; cell surface receptor; IL-8; bacterial N-formyl peptide;

    Sammanfattning : Neutrophil activation is the most important initial immune defense against invading microbes in newborn infants. The reduced neutrophil migration and uncontrolled regulation of reactive oxygen species (ROS) production observed in neonates, could result in a diminished infectious response or in tissue damage. LÄS MER

  7. 5. Somatostatin, dendritic cells and peptide T in psoriasis : a clinical, immunohistochemical and functional study

    Författare :Toomas Talme; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Peptide T is an octapeptide designed to block the CD4 receptor. In a phase 1 study 9 psoriasis patients were treated with 2 mg peptide T i.v. once daily for 28 days and followed for a further 3 months. LÄS MER