Sökning: "serotonin transporter"

Visar resultat 11 - 15 av 52 avhandlingar innehållade orden serotonin transporter.

1. 11. Gene-Environment Interaction in Adolescent Deviant Behaviour

   Författare :Kent W. Nilsson; Leif Lindström; Lars Oreland; Jerzy Leppert; John Öhrvik; Rickard L. Sjöberg; Marie Åsberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurobiology; Adolescent; Alcohol; Criminology; Genes; Environment; Monoamine Oxidase; Serotonin; Social Support; Neurobiologi; Neurobiology; Neurobiologi;

   Sammanfattning : The overall aim of this thesis was to explore gene-environmental (G*E) interactions in relation to deviant behaviour among 200 Swedish adolescents, with a focus on criminality, alcohol consumption and depressive symptoms. Those behaviours have been extensively investigated in relation to both psychosocial and biological risk factors. LÄS MER

3. 12. Platelet monoamine oxidase : From genetic regulation to behavior

   Författare :Håkan Garpenstrand; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; monoamine oxidase; platelet; personality; CNS; serotonin; dopamine; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

   Sammanfattning : Genetic and environmental factors contribute to the development of personality and vulnerability forpsychiatric disorders. The activity of monoamine oxidase in platelets (trbc-MAO), which is mainlygenetically determined, correlates to personality traits such as sensation-seeking and impulsiveness, andlow trbc-MAO activity is more common in patients with type 2 alcoholism. LÄS MER

4. 13. PET studies of the serotonin transporter in the human brain

   Författare :Johan Lundberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :positron emission tomography; MADAM; WAY 100635; 5-HTT; 5-HT1A receptors; receptor occupancy; major depressive disorder; citalopram; escitalopram;

   Sammanfattning : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. LÄS MER

5. 14. Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization

   Författare :Cecilia Mattsson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dopamine D2 receptor; serotonin reuptake transporter; monoamine oxidase; 5-HT6 receptor; DOPAC; 5-HIAA; 3-tetrahydropyridine indole; 3-piperidine indole; 3- pyrrolidin-1-ylmethyl chromen-2-one; dopamine D2 receptor;

   Sammanfattning : It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and current therapies are still based on this mechanism. However, all available antidepressants today are still suffering from slow onset of therapeutic action, as well as adverse effects and lack of efficacy. LÄS MER

7. 15. Platelet serotonin function and personality traits in affective disorder

   Författare :Jolanta Neuger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Serotonin; depression; panic disorder; platelets; personality; citalopram;

   Sammanfattning : Serotonin (5-HT, 5-hydroxytryptamine) is a neurotransmitter in the central nervous system which has been implicated m the aetiology and pathogenesis of affective disorders like depression and anxiety disorders. The serotonergic system has been shown to be involved in the modulation of mood, sleep, appetite, libido, energy and cognition and memory functions. LÄS MER