Sökning: "3-piperidine indole"

Hittade 1 avhandling innehållade orden 3-piperidine indole.

  1. 1. Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization

    Författare :Cecilia Mattsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dopamine D2 receptor; serotonin reuptake transporter; monoamine oxidase; 5-HT6 receptor; DOPAC; 5-HIAA; 3-tetrahydropyridine indole; 3-piperidine indole; 3- pyrrolidin-1-ylmethyl chromen-2-one; dopamine D2 receptor;

    Sammanfattning : It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and current therapies are still based on this mechanism. However, all available antidepressants today are still suffering from slow onset of therapeutic action, as well as adverse effects and lack of efficacy. LÄS MER