Sökning: "satellite cell"
Visar resultat 21 - 25 av 39 avhandlingar innehållade orden satellite cell.
21. Recruitment of circulating cells into skeletal muscle : occurrence and possible mechanisms
Sammanfattning : Tissue remodeling is a central process for all life. When a tissue is exposed to environmental stress such as injury, both local cells and cells from the periphery are recruited to regenerate and remodel the tissue. During the last decades the importance of resident cells, e.g. LÄS MER
22. Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia
Sammanfattning : The aim of this thesis was to analyze the genetic and epigenetic characteristics of pediatric high hyperdiploid acute lymphoblastic leukemia (HeH ALL), the most common type of childhood malignancy. The three original articles presented in this thesis have addressed three major questions regarding HeH ALL: what are the genetic characteristics of the most common structural abnormality – dup(1q)? Are aberrant methylation patterns involved in leukemogenesis? How do diagnostic and relapse samples relate to each other genetically? In article I we found that the proximal breakpoints of dup(1q)-positive Burkitt lymphomas (BL) and pediatric HeH ALLs cluster close to the centromere, suggesting this region to be breakprone, and that five genes on 1q were significantly overexpressed and thus potentially pathogenetically important. LÄS MER
23. Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours
Sammanfattning : Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. LÄS MER
24. Immunological changes in human blood and skeletal muscle in response to physical exercise
Sammanfattning : Physical exercise is essential for maintaining normal function of skeletal muscle. Muscle tissue also has a remarkable capacity for adaptation to changes in physical demand. In fact, without stimulation from physical activity, muscle tissue will atrophy. LÄS MER
25. The dynamic chromosphere : Results and techniques with an observational approach
Sammanfattning : The chromosphere is a critical interface between the relatively cold photosphere and the hot corona. Its landscape is rich in very dynamic phenomena such as jets, spicules, and surges, which are thought to play an important role in the heating of the Sun’s upper atmosphere. LÄS MER